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| http://dx.doi.org/10.1097/WNO.0000000000001834 | DOI Listing |
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Cytomegalovirus-Induced Optic Neuritis Through Cerebrospinal Fluid Viral Transmission in an Immunocompetent Patient: A Case Report.
J Neuroophthalmol
June 2024
Department of Ophthalmology (ST, NH, KM, RO, TM, KN), Osaka University Graduate School of Medicine, Osaka, Japan; Department of Ophthalmology (ST), Higashiosaka City Medical Center, Osaka, Japan; Integrated Frontier Research for Medical Science Division (KM, KN), Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Osaka, Japan; Advanced Visual Neuroscience (TM), Osaka University Graduate School of Medicine, Osaka, Japan; and Department of Neurology (RS), Osaka University Graduate School of Medicine, Osaka, Japan.
Clinical Metagenomic Next-Generation Sequencing for Diagnosis of Secondary Glaucoma in Patients With Cytomegalovirus-Induced Corneal Endotheliitis.
Front Microbiol
July 2022
The Children's Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou, China.
Glaucoma is the second leading cause of blindness globally. Growing scientific evidence indicated that inflammation of the trabecular meshwork induced by corneal endotheliitis could lead to secondary glaucoma. Cytomegalovirus (CMV) has been identified as the most common herpes virus in corneal endotheliitis patients.
View Article and Find Full Text PDFGanciclovir attenuates the onset and progression of experimental autoimmune uveitis by inhibiting infiltration of Th17 and inflammatory cells into the retina.
Biochem Pharmacol
March 2022
Institute of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, China. Electronic address:
Noninfectious (autoimmune and immune-mediated) uveitis is one of the primary diseases leading to blindness in the world. Due to the limitation of current first-line drugs for clinical uveitis, novel drugs and targets against uveitis are urgently needed. Ganciclovir (GCV), an FDA-approved antiviral drug, is often used to treat cytomegalovirus-induced retinitis in clinical patients.
View Article and Find Full Text PDFSelf-Injurious Behavior Secondary to Cytomegalovirus-Induced Neuropathy in an SIV-Infected Rhesus Macaque (Macaca mulatta).
Comp Med
June 2015
Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
A 3.5-y-old, female rhesus macaque (Macaca mulatta) inoculated with SIVmac239 presented 8 mo later for inappetence and facial bruising. Physical examination revealed a superficial skin abrasion below the left eye, bruising below the left brow, and epistaxis of the left nostril.
View Article and Find Full Text PDFDecrease of murine cytomegalovirus-induced retinitis by intravenous delivery of immediate early protein-3-specific siRNA.
Invest Ophthalmol Vis Sci
June 2014
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia, United States.
Purpose: Retinitis induced by both human and murine cytomegaloviruses following immunosuppression is characterized by progressive loss of retinal architecture, due to necrosis of virus-infected cells as well as widespread apoptosis of uninfected bystander cells. Because small inhibitory RNA molecules (siRNA) can reduce murine cytomegalovirus (MCMV) gene expression and thereby inhibit virus replication in vitro, we tested siRNAs directed against MCMV immediate early protein-3 (IE-3) to determine if MCMV-induced retinitis could be alleviated in vivo.
Methods: Immunosuppressed Balb/c mice (2.
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