Background: Cardiovascular events and poor quality of life are frequently observed in patients with coronary slow flow phenomenon (CSFP). This trial evaluated the effect of nano-curcumin supplement containing curcuminoids, as multifunctional nutraceuticals, on angina status, and some traditional and novel cardiovascular risk factors in overweight or obese patients with CSFP.
Methods: In this double-blind, randomized, placebo-controlled clinical trial, 42 overweight or obese patients with CSFP received either 80 mg/day of nano-curcumin or placebo for 12 weeks. Seattle angina questionnaire (SAQ) as a clinical measure of angina status, circulating endocan, adropin, homocysteine, lipid profile, and the novel scores of visceral adiposity index (VAI) and waist-triglyceride index (WTI) were assessed before and after the intervention. The independent samples t-test, Mann-Whitney test, analysis of covariance, Chi-square, and Fisher's exact tests were used where appropriate.
Results: All domains of SAQ including physical limitation, angina stability, angina frequency-severity, treatment satisfaction, and disease perception and quality of life improved significantly in the nano-curcumin compared with the placebo group. No significant changes were observed in serum endocan, adropin, and homocysteine following the intervention. Triglycerides, triglyceride/high-density lipoprotein cholesterol ratio, WTI and VAI values improved significantly only within the nano-curcumin group.
Conclusions: Supplementation with 80 mg/day nano-curcumin (containing curcuminoids) for 12 weeks significantly improved clinically important disease-specific aspects of health in patients with CSFP. Some traditional and novel cardiovascular risk factors improved significantly only compared with the baseline values, which need further investigation.
Trial Registration: This study was approved by the Ethics Committee of Tehran University of Medical Sciences (IR.TUMS.VCR.REC.1398.794). The study protocol was registered at Iranian Registry of Clinical Trials by IRCT20131125015536N8 registration ID at 19.06.2019.
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http://dx.doi.org/10.1186/s40795-024-00877-3 | DOI Listing |
Healthcare (Basel)
November 2024
Department of Financial Economics and Accounting, Faculty of Business, Finance and Tourism, University of Extremadura, Avda. de la Universidad, s/n, 10071 Cáceres, Spain.
Introduction: Evidence supports the relationships between socioeconomic status and access to health care, incidence of pathologies, and lifestyle.
Objective: The aim of this research was to investigate whether there are associations between having a household income below the poverty line, and participation in unhealthy lifestyle habits, the prevalence of non-communicable diseases, and the number of comorbidities in US middle-aged and older adults.
Methods: This cross-sectional study is based on the NHANES 2011-2020.
Am J Transl Res
November 2024
Department of General Medicine, Ankang Centre Hospital Ankang 725000, Shaanxi, China.
Objective: To assess the effect of psychocardiology-based nursing intervention on cardiac function and self-efficacy in elderly patients with angina pectoris.
Methods: A total of 127 elderly patients with angina pectoris admitted to the First Affiliated Hospital of Xi'an Jiaotong University from December 2022 to December 2023 were divided into two groups: the control group (n=63) received routine nursing care, while the observation group (n=64) received psychocardiology-based nursing intervention in addition to routine care. The psychological status, self-efficacy, cardiac function, and severity of angina were compared between the two groups before and after intervention.
Front Cardiovasc Med
November 2024
Department of Anesthesiology, People's Hospital of Longhua, Shenzhen, China.
Background And Aim: Estimated glomerular filtration rate (eGFR) is a key indicator of kidney function and is associated with numerous health conditions. This study examines the association between eGFR and cardiovascular disease (CVD) risk in a representative cohort of the US adult population.
Methods: A cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018.
Am Heart J
December 2024
University of Missouri-Kansas City's Healthcare Institute for Innovations in Quality, Kansas City, MO; Saint Luke's Mid America Heart Institute, Kansas City, MO.
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