AI Article Synopsis
- Dopamine neurons in the ventral tegmental area play a key role in intracranial self-stimulation (ICSS), but their exact cognitive functions are still not fully understood.
- 20-Hz stimulation of dopamine neurons mimics a weak prediction error and fails to support ICSS beyond a simple reinforcement schedule, lacking the ability to assign value to cues.
- In contrast, 50-Hz stimulation significantly enhances ICSS, providing a specific reward representation that motivates behavior, indicating that the frequency of stimulation affects dopamine release modulations.
Article Abstract
Dopamine neurons in the ventral tegmental area support intracranial self-stimulation (ICSS), yet the cognitive representations underlying this phenomenon remain unclear. Here, 20-Hz stimulation of dopamine neurons, which approximates a physiologically relevant prediction error, was not sufficient to support ICSS beyond a continuously reinforced schedule and did not endow cues with a general or specific value. However, 50-Hz stimulation of dopamine neurons was sufficient to drive robust ICSS and was represented as a specific reward to motivate behavior. The frequency dependence of this effect is due to the rate (not the number) of action potentials produced by dopamine neurons, which differently modulates dopamine release downstream.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11239488 | PMC |
| http://dx.doi.org/10.1038/s41593-024-01643-1 | DOI Listing |
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