Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41563-024-01898-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multi-Target Inhibitor CUDC-101 Impairs DNA Damage Repair and Enhances Radiation Response in Triple-Negative Breast Cell Line.
Pharmaceuticals (Basel)
November 2024
Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0028, South Africa.
Article Synopsis
- - The study investigates CUDC-101, a multitarget inhibitor, and its ability to improve radiation response in breast cancer when combined with proton and X-ray irradiation, with a focus on triple-negative breast cancer cell lines.
- - Results showed that CUDC-101 enhanced sensitivity to radiation, increased apoptosis, and caused G2/M cell cycle arrest, particularly in the aggressive MDA-MB-231 cell line.
- - The findings suggest that CUDC-101 could be an effective option for treating triple-negative breast cancer, either on its own or alongside radiation therapies.
Contemporary Role of Radiation Therapy in Testicular Cancer.
Urol Clin North Am
August 2024
Department of Radiation Oncology, University of Kansas Cancer Center, 4001 Rainbow Boulevard, Kansas City, KS 66160, USA.
Testicular cancer is a rare but curable male malignancy. Seminoma represents the majority of germ cell tumors and is considered radiation sensitive. Radiation treatment plays a role in adjuvant therapy after orchiectomy of stage I, IIA, and IIB seminomas.
View Article and Find Full Text PDFInvestigation of intra-fractionated range guided adaptive proton therapy: I. On-line PET imaging and range measurement.
Phys Med Biol
July 2024
Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75057, United States of America.
Develop a prototype on-line positron emission tomography (PET) scanner and evaluate its capability of on-line imaging and intra-fractionated proton-induced radioactivity range measurement.Each detector consists of 32 × 32 array of 2 × 2 × 30 mmLutetium-Yttrium Oxyorthosilicate scintillators with single-scintillator-end readout through a 20 × 20 array of 3 × 3 mmSilicon Photomultipliers. The PET can be configurated with a full-ring of 20 detectors for conventional PET imaging or a partial-ring of 18 detectors for on-line imaging and range measurement.
View Article and Find Full Text PDFSensitive proton-radiation detectors.
Nat Mater
June 2024
Chemistry and Nanoscience Science Center, National Renewable Energy Laboratory, Golden, CO, USA.
Radiation Dose Sensitivity of Subregions of the Larynx to Patient-Reported Swallowing Outcomes.
Adv Radiat Oncol
May 2024
Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Purpose: To assess any correlation between swallowing dysfunction and radiation dose to 5 subregions of the larynx.
Methods And Materials: A cohort of 136 patients with head and neck cancer, treated with either photon or proton radiation therapy, was assessed using an endpoint of patient-reported swallowing scores, evaluated with the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire-H&N35 survey, within 1 month after treatment. Five subregions of the larynx were contoured, and dosimetric metrics were extracted for each subregion as well as the total larynx.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!