Phorbol () has a tetracyclic ABCD-ring and is readily isolable from a natural source. We previously synthesized and 16 structurally related natural products using common ABC-ring intermediate . Here we report a new synthetic route to using as a starting material. Key features of the synthesis are chemoselective removal of the D-ring via cyclopropane opening, peroxidation, and retro-aldol reactions. The high utility of the peroxidation was further demonstrated in the first synthesis of crotonianoid B ().
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