CD44 is a ubiquitous leukocyte adhesion molecule involved in cell-cell interaction, cell adhesion, migration, homing and differentiation. CD44 can mediate the interaction between leukemic stem cells and the surrounding extracellular matrix, thereby inducing a cascade of signaling pathways to regulate their various behaviors. In this review, we focus on the impact of CD44s/CD44v as biomarkers in leukemia development and discuss the current research and prospects for CD44-related interventions in clinical application.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11082360 | PMC |
| http://dx.doi.org/10.3389/fimmu.2024.1354992 | DOI Listing |
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