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Aims: Diabetes mellitus (DM) induces increased inflammation of atherosclerotic plaques, resulting in elevated plaque instability. Mesenchymal stem cell (MSC) therapy was shown to decrease plaque size and increase stability in non-DM animal models. We now studied the effect of MSC therapy in a streptozotocin-induced hyperglycaemia mouse model using a clinically relevant dose of adipose tissue-derived MSCs (ASCs).

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Objectives: The current experiment was conducted to investigate the combined effect of levofloxacin (LVX) and metformin treatment on blood glucose levels, malondialdehyde (MDA),nitrite levels, and anxiety in streptozotocin (STZ)+ nicotine adenine dinucleotide (NAD)-induced diabetic rats.

Materials And Methods: In this study, Wistar rats have been used. After receiving a single dose of STZ + NAD (45 mg/kg, + 50 mg/kg, ), the rats developed diabetes.

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Dissecting the mechanisms of velvet antler extract against diabetic osteoporosis via network pharmacology and proteomics.

J Ethnopharmacol

January 2025

Northeast Asia Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, Jilin Province, China. Electronic address:

Ethnopharmacological Relevance: Velvet antler (VAE) is a famous traditional Chinese medicine (TCM), which has been used for thousands of years to treat bone-related diseases. Nonetheless, whether VAE has anti-diabetic osteoporosis (DOP) properties remains to be elucidated.

Aim Of The Study: The therapeutic mechanism of VAE on DOP is based on integrated proteomics of network pharmacology strategies to study related targets and pathways.

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Investigating the Molecular Mechanisms of Jiangu Decoction in Treating Type 2 Diabetic Osteoporosis.

J Ethnopharmacol

January 2025

Northeast Asia Research Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, Jilin Province, China; Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, Jilin Province, China. Electronic address:

Ethnopharmacological Relevance: Type 2 diabetic osteoporosis (T2DOP) is a metabolic bone disease characterized by impaired bone structure and decreased bone strength in diabetic patients. Jiangu Decoction (JGD), a traditional Chinese poly-herbal formulation, has shown efficacy in mitigating osteoporosis (OP) and fractures caused by osteoporosis in diabetic patients in clinical trials. In addition, JGD has been proven to promote the proliferation of osteoblasts.

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Role of antioxidative stress activity of Fucoxanthin nanoparticle as hepatoprotective in diabetic rats.

Pak J Pharm Sci

January 2025

Department of Basic Veterinary Medicine, Faculty of Veterinary Medicine, Airlangga, University, Surabaya, Indonesia.

This study attempts to prove that the antioxidant effect of fucoxanthin nanoparticles can prevent streptozotocin-induced rat liver damage. Fucoxanthin nanoparticles are synthesized using the high-energy ball milling method. Dynamic Light Scattering (DLS) was then used to describe the sizes of the fucoxanthin nanoparticles.

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