Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S0140-6736(24)00481-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Gentamicin and clindamycin antibiotic-eluting depot technology eradicates in an implant-associated osteomyelitis pig model without systemic antibiotics.
Antimicrob Agents Chemother
October 2024
Department of Health Technology, Technical University of Denmark, Kgs. Lyngby, Denmark.
The therapeutic challenges of orthopedic device-related infections and emerging antimicrobial resistance have attracted attention to drug delivery technologies. This study evaluates the preclinical efficacy of local single- and dual-antibiotic therapy against implant-associated osteomyelitis (IAO) using a drug-eluting depot technology, CarboCell, that provides sustained release of high-dose antibiotics and allows for strategic placement in relation to infectious lesions. Clindamycin and gentamicin were formulated in CarboCell compositions.
View Article and Find Full Text PDFCement loaded with high-dose gentamicin and clindamycin does not reduce the risk of subsequent infection after aseptic total hip or knee revision arthroplasty: a preliminary study.
J Orthop Traumatol
July 2024
Department of Orthopaedic Surgery, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Purpose: The aim of this study was to quantify the prophylactic effect of high-dose gentamicin and clindamycin antibiotic-loaded bone cement (ALBC) during revision total hip (rTHA) or knee (rTKA) arthroplasty for aseptic reasons. The hypothesis was that the raw surgical site infection (SSI) rate is lower when this particular cement is used in comparison with cement loaded with standard-dose gentamicin during rTHA or rTKA for aseptic reasons.
Methods: This retrospective study included 290 consecutive patients undergoing aseptic rTHA or rTKA.
Fever of unknown origin revealing testicular nocardiosis: a case report and literature review.
BMC Infect Dis
June 2024
Department of Internal Medicine, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium.
Article Synopsis
- Nocardia is a common soil organism that can cause opportunistic infections, primarily affecting the lungs and skin, but rare cases can involve the testis.
- The report details a 75-year-old immunocompromised man who developed epididymo-orchitis and necrotic abscesses after exposure to Nocardia brasiliensis, leading to complex treatment that included surgery and prolonged antibiotic therapy.
- This case is notable as it is the first documented instance of Nocardia brasiliensis affecting multiple body sites (skin, testis, brain, and spinal cord), emphasizing the challenges in diagnosing atypical nocardiosis and highlighting the need for timely bacterial culture.
High-dose dual-antibiotic loaded cement for hip hemiarthroplasty - Authors' reply.
Lancet
May 2024
Oxford Trauma and Emergency Care, Kadoorie Centre, University of Oxford, Oxford OX3 9DU, UK. Electronic address:
High-dose dual-antibiotic loaded cement for hip hemiarthroplasty.
Lancet
May 2024
Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan. Electronic address:
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!