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Focused ion beam (FIB) prepared microtextured microneedle array capable of delivering drugs through punctured skin.
Sci Rep
December 2024
School of Mechanical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.
Microtextured microneedles are tiny needle-like structures with micron-scale microtextures, and the drugs stored in the microtextures can be released after entering the skin to achieve the effect of precise drug delivery. In this study, the skin substitution model of Ogden's hyperelastic model and the microneedle array and microtexture models with different geometrical parameters were selected to simulate and analyse the flow of the microtexture microneedle arrays penetrating the skin by the finite-element method, and the length of the microneedles was determined to be 200 μm, the width 160 μm, and the value of the gaps was determined to be 420 μm. A four-pronged cone was chosen as the shape of microneedles, and a rectangle was chosen as the shape of the drug-carrying microneedle.
View Article and Find Full Text PDFDetection and Characterization of Multidimensional Information of Adipocyte Model Based on AFM-Raman.
Microsc Res Tech
November 2024
International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun, China.
Excessive accumulation of white adipose tissue leads to metabolic disorders, and the excessive differentiation of preadipocytes into white adipocytes is one of the contributing factors to obesity. The browning of white adipocytes has been regarded as a promising therapeutic strategy. To analyze the origins and potential solutions for obesity from a fundamental perspective, we employed atomic force microscopy, and Raman confocal microscopy to investigate and characterize multidimensional information regarding the differentiation process of 3 T3-L1 preadipocyte models into white adipocytes and their subsequent browning into beige adipocytes.
View Article and Find Full Text PDFCounterillumination reduces bites by Great White sharks.
Curr Biol
December 2024
School of Natural Sciences, Macquarie University, North Ryde, NSW 2109, Australia. Electronic address:
In the open ocean, achieving camouflage is complicated by the fact that the downwelling light is generally much brighter than the upwelling light, which means that any object, even if its ventral surface is white due to countershading, will appear as a dark silhouette when viewed from below. To overcome this, many marine species employ counterillumination, whereby light is emitted from photophores on their ventral surface to replace the downwelling light blocked by their body. However, only a single behavioral study has tested the efficacy of counterillumination as an anti-predation strategy.
View Article and Find Full Text PDFCultivating Physical and Mental Wellness: The Impact of Storytelling and Puzzle Sessions on Generational Change.
Cureus
August 2024
Pathology, All India Institute of Medical Sciences (AIIMS), Madurai, IND.
In the urban landscape of Chennai, a pathologist, deeply concerned about the future of the younger generation, initiated a community-driven initiative aimed at fostering physical and mental wellness among children. Through a blend of captivating storytelling and stimulating puzzle sessions, the initiative sought to combat trends of laziness, gadget dependency, and poor dietary habits prevalent among youth. The sessions, designed to engage young minds while imparting valuable life lessons and problem-solving skills, garnered remarkable responses from participants and parents alike.
View Article and Find Full Text PDFChallenges and prospects in advancing clinical neuropsychology.
Cortex
October 2024
Clinical and Experimental Neuropsychology Laboratory, Faculty of Psychology, University of Geneva, Switzerland. Electronic address:
In the ever-evolving field of clinical neuropsychology, significant methodological and conceptual limitations hinder progress. To ensure the continued relevance of this discipline amidst remarkable advancements in neuroscience, medicine, and methodology, these obstacles must be addressed. This opinion article identifies inherent limitations within current clinical neuropsychology, including issues such as multi-collinearity in neuropsychological assessments, lack of validated tools reflecting contemporary cognitive function models, and the use of divergent theoretical frameworks in evaluations, leading to a gap between theory and practice.
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