AI Article Synopsis
- Creating scar models in lab animals is essential for preclinical testing of scar treatments, but challenges arise due to the rapid skin regeneration in rodents.
- Five methods have been tested in rats to create scar tissue models, each resulting in distinct histopathological characteristics and varying stages of skin scar development.
- These techniques aim to improve the understanding of scar formation and support the development of effective treatments.
Article Abstract
Creating of a scar model in laboratory animals is the most acceptable option for the preclinical search of scar treatment. However, due to high skin regeneration rate in laboratory rodents, creating an optimal animal model of scar formation is a challenge. Here we describe five methods for modeling a scar tissue in rats that we have tested. These methods allowed achieving different histopathological features and different stages of skin scar formation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-024-06084-1 | DOI Listing |
Publication Analysis
Top Keywords
scar formation
8
scar
6
experimental approaches
4
approaches scar
4
scar modeling
4
modeling mechanical
4
mechanical skin
4
skin damage
4
damage chemical
4
chemical burn
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!