Thymol, a Monoterpenoid within Polymeric Iodophor Formulations and Their Antimicrobial Activities.

Int J Mol Sci

Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman P.O. Box 346, United Arab Emirates.

Published: May 2024

AI Article Synopsis

  • * The study investigates a new formulation combining Miller (AV), Thymol, iodine (I), and polyvinylpyrrolidone (PVP) as a potential antimicrobial solution against resistant pathogens, using various analytical methods for validation.
  • * Results show that the AV-PVP-Thymol-I formulation demonstrates strong antibacterial and antifungal activity, particularly on surgical materials, suggesting its use in treating wound infections and as a contact-killing agent.

Article Abstract

Antimicrobial resistance (AMR) poses an emanating threat to humanity's future. The effectiveness of commonly used antibiotics against microbial infections is declining at an alarming rate. As a result, morbidity and mortality rates are soaring, particularly among immunocompromised populations. Exploring alternative solutions, such as medicinal plants and iodine, shows promise in combating resistant pathogens. Such antimicrobials could effectively inhibit microbial proliferation through synergistic combinations. In our study, we prepared a formulation consisting of Miller (AV), Thymol, iodine (I), and polyvinylpyrrolidone (PVP). Various analytical methods including SEM/EDS, UV-vis, Raman, FTIR, and XRD were carried out to verify the purity, composition, and morphology of AV-PVP-Thymol-I. We evaluated the inhibitory effects of this formulation against 10 selected reference strains using impregnated sterile discs, surgical sutures, gauze bandages, surgical face masks, and KN95 masks. The antimicrobial properties of AV-PVP-Thymol-I were assessed through disc diffusion methods against 10 reference strains in comparison with two common antibiotics. The 25-month-old formulation exhibited slightly lower inhibitory zones, indicating changes in the sustained-iodine-release reservoir. Our findings confirm AV-PVP-Thymol-I as a potent antifungal and antibacterial agent against the reference strains, demonstrating particularly strong inhibitory action on surgical sutures, cotton bandages, and face masks. These results enable the potential use of the formulation AV-PVP-Thymol-I as a promising antimicrobial agent against wound infections and as a spray-on contact-killing agent.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11084924PMC
http://dx.doi.org/10.3390/ijms25094949DOI Listing

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