The expression of polysialic acid (polySia) on the neuronal cell adhesion molecule (NCAM) is called NCAM-polysialylation, which is strongly related to the migration and invasion of tumor cells and aggressive clinical status. Thus, it is important to select a proper drug to block tumor cell migration during clinical treatment. In this study, we proposed that lactoferrin (LFcinB11) may be a better candidate for inhibiting NCAM polysialylation when compared with CMP and low-molecular-weight heparin (LMWH), which were determined based on our NMR studies. Furthermore, neutrophil extracellular traps (NETs) represent the most dramatic stage in the cell death process, and the release of NETs is related to the pathogenesis of autoimmune and inflammatory disorders, with proposed involvement in glomerulonephritis, chronic lung disease, sepsis, and vascular disorders. In this study, the molecular mechanisms involved in the inhibition of NET release using LFcinB11 as an inhibitor were also determined. Based on these results, LFcinB11 is proposed as being a bifunctional inhibitor for inhibiting both NCAM polysialylation and the release of NETs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11083048 | PMC |
| http://dx.doi.org/10.3390/ijms25094641 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Supplementation of 3'-Sialyllactose During the Growth Period Improves Learning and Memory Development in Mice.
J Agric Food Chem
November 2024
State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China.
Article Synopsis
- 3'-Sialyllactose (3'-SL), a key component found in human milk, was given to 3-week-old C57BL/6 mice for 6 weeks to study its effects on cognitive development and memory.
- The study showed significant improvements in cognitive abilities and memory in the mice, linked to an increase in specific genes in their hippocampal tissue related to learning.
- Furthermore, 3'-SL altered the mice's gut microbiota, which, in combination with enzyme activity, enhanced the availability of sialic acid, supporting brain development and indicating potential pathways for cognition enhancement.
NCAM and attached polysialic acid affect behaviors of breast epithelial cells through differential signaling pathways.
Acta Biochim Biophys Sin (Shanghai)
October 2024
Provincial Key Laboratory of Biotechnology, Joint International Research Laboratory of Glycobiology and Medicinal Chemistry, School of Medicine, Northwest University, Xi'an 710069, China.
Neural cell adhesion molecule (NCAM), a common mammalian cell surface glycoprotein, is the major substrate of polysialic acid (polySia). Polysialylated NCAM occurs in many types of cancer, but rarely in normal adult tissues. The functional role of NCAM hypersialylation in the epithelial-mesenchymal transition (EMT) process remains unclear.
View Article and Find Full Text PDFEarly PSA-NCAM reduction in the dentate gyrus and impaired plasticity in the Alzheimer´s disease 3xTg-mice model.
Acta Histochem
December 2024
Laboratory of Molecular Cell Biomedicine, Department of Biology, University of the Balearic Islands, Palma 07122, Spain. Electronic address:
Neurodegenerative diseases such as Alzheimer´s (AD) and physiological ageing are characterized by a decline in neurogenesis and in the polysialylated isoforms of neural cell adhesion molecule (PSA-NCAM) expression within the hippocampus and specifically in the dentate gyrus (DG). In the 3xTG-AD mouse model, which mimics the human disease in both pathological and behavioral features, this decline in PSA-NCAM is associated with the presence of Aβ plaques at 9 months and Tau tangles at 12-15 months. In this work we studied the presence of PSA-NCAM at early ages (1-6 months) in the same model.
View Article and Find Full Text PDFLong term effects of peripubertal stress on the thalamic reticular nucleus of female and male mice.
Neurobiol Dis
October 2024
Neurobiology Unit, Institute for Biotechnology and Biomedicine (BIOTECMED), Universitat de València, 46100, Spain; Spanish National Network for Research in Mental Health CIBERSAM, 28029, Spain; Fundación Investigación Hospital Clínico de Valencia, INCLIVA, 46010 Valencia, Spain. Electronic address:
Adverse experiences during infancy and adolescence have an important and enduring effect on the brain and are predisposing factors for mental disorders, particularly major depression. This impact is particularly notable in regions with protracted development, such as the prefrontal cortex. The inhibitory neurons of this cortical region are altered by peripubertal stress (PPS), particularly in female mice.
View Article and Find Full Text PDFResveratrol as modulator of PSA-NCAM expression in the hippocampus of diazinon-injured rat fetuses.
Neurosci Lett
July 2024
Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran. Electronic address:
Polysialylated neural cell adhesion molecule (PSA-NCAM) is expressed in the developing central nervous system (CNS) and plays an important role in neurogenesis. Organophosphorus (OP) toxins, including diazinon (DZN), cause oxidative stress (OS) and damage the CNS. Resveratrol (RV), with its antioxidant effect, leads to the reduction of OS.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!