Although the wide variety of bioactivities of curcumin has been reported by researchers, the clinical application of curcumin is still limited due to its poor aqueous solubility. In view of this, a series of dimethylaminomethyl-substituted curcumin derivatives were designed and synthesized (compounds -). Acetate of these derivatives were prepared (compounds -). The Mannich reaction and aldol condensation reaction are the main reactions involved in this study. Compounds , , , , , , , , , , , , , and exhibited better in vitro anti-inflammatory activity compared to curcumin in the RAW264.7 cell line. Compounds , , , , and exhibited better in vitro antioxidant activity compared to curcumin in the PC 12 cell line. Compounds , , , , and exhibited better in vitro radiation protection compared to curcumin in the PC 12 cell line. The aqueous solubilities of all the curcumin derivative acetates were greatly improved compared to curcumin.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11085442 | PMC |
| http://dx.doi.org/10.3390/molecules29091985 | DOI Listing |
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