A chemical investigation of the arils of led to the isolation of seven abietane-type diterpenoids (compounds -) including three previously undescribed compounds, one unreported natural product, and three known analogs. The structures of these compounds were determined by means of spectroscopy, single-crystal X-ray diffraction, and ECD spectra. An antibacterial activity assay showed that compounds and had significant inhibitory effects on methicillin-resistant , with MIC values of 100 μM. Moreover, compounds , , , and exhibited anti-neuroinflammatory activity in LPS-stimulated BV-2 microglia cells, with the IC values ranging from 38.4 to 67.9 μM.
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| http://dx.doi.org/10.3390/molecules29091905 | DOI Listing |
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