AI Article Synopsis
- Platelets store serotonin (5-HT), which is important for liver regeneration, and this study explores its effects on outcomes after orthotopic liver transplantation (OLT).
- Analysis of 44 OLT recipients revealed that higher levels of donor intra-platelet 5-HT were associated with lower postoperative liver enzyme levels, suggesting better recovery.
- Although there was no significant link between serotonin levels and early allograft dysfunction (EAD), a trend indicated that lower donor serotonin might be connected to higher EAD rates, pointing to the need for further research with more participants.
Article Abstract
Platelets were shown to be relevant for liver regeneration. In particular, platelet-stored serotonin (5-HT) proved to be a pro-regenerative factor in this process. The present study aimed to investigate the perioperative course of 5-HT and evaluate associations with patient and graft outcomes after othotopic liver transplantation (OLT). 5-HT was quantified in plasma and serum of 44 OLT recipients perioperatively, and in their respective donors. Olthoff's criteria for early allograft dysfunction (EAD) were used to evaluate postoperative outcomes. Patients with higher donor intra-platelet 5-HT per platelet (IP 5-HT PP) values had significantly lower postoperative transaminases (ASAT POD1: = 0.006, ASAT POD5: = 0.006, ASAT POD10: = 0.02, ALAT POD1: = 0.034, ALAT POD5: = 0.017, ALAT POD10: = 0.04). No significant differences were seen between postoperative 5-HT values and the occurrence of EAD. A tendency was measured that donor IP 5-HT PP is lower in donor-recipient pairs that developed EAD ( = 0.07). Donor IP 5-HT PP might be linked to the postoperative development of EAD after OLT, as higher donor levels are correlated with a more favorable postoperative course of transaminases. Further studies with larger cohorts are needed to validate these findings.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11084934 | PMC |
| http://dx.doi.org/10.3390/jcm13092640 | DOI Listing |
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