: Dry eye disease (DED) stands out as one of the most common eye conditions encountered in clinical settings. This study aimed to determine the diagnostic ability and feasibility of post-blink blur time (PBBT) in detecting patients with DED symptoms. : The study included 200 subjects, 100 with and 100 without DED symptoms defined by the Schein questionnaire, who underwent assessment of DED signs [visual acuity, PBBT, conjunctival hyperemia, lid-parallel conjunctival folds-LIPCOF, tear film break-up time-TBUT, fluorescein corneal staining, and meibum score]. : DED subjects had a lower PBBT than controls ( < 0.001), with subjective (6 (1-45) s vs. 8 (1-70) s) and objective (6 (2-33) s vs. 8 (2-50) s) PBBT measurements being similar between repeats. The correlations between subjective and objective PBBT measurements were significantly positive (R = 0.873, < 0.001). Subjective PBBT was negatively related to the Schein questionnaire (R = -0.217, = 0.002), conjunctival hyperemia (R = -0.105, = 0.035), and corneal staining (R = -0.153, = 0.031), while positively related to the TBUT (R = 0.382, < 0.001) and meibum score (R = 0.106, = 0.033). Logistic regression analysis showed DED symptoms were significantly associated with subjective PBBT (AOR 0.91, = 0.001), TBUT (AOR 0.79, < 0.001), meibum score (AOR 0.65, = 0.008), LIPCOF (AOR 1.18, = 0.002) and corneal staining (AOR 1.14, = 0.028). : Subjective self-reported PBBT is a reliable and non-invasive screening test for evaluating time-wise changes in visual acuity and detecting a tear film dysfunction.

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http://dx.doi.org/10.3390/jcm13092473DOI Listing

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