AI Article Synopsis
- Malignant spinal lesions (MSLs) often signal advanced cancer, making quick and effective spinal care vital for patient outcomes.
- The study compared cytopathology (CP) and histopathology (HP) in 61 patients, finding that CP provided a mean time to diagnosis (TTD) of 1.7 days versus 8.4 days for HP, significantly speeding up care.
- Results indicate that CP not only shortens TTD and time to therapy (TTT) but may also improve treatment initiation and overall patient quality of life, suggesting it should be standard practice for MSL evaluation.
Article Abstract
Malignant spinal lesions (MSLs) are frequently the first manifestation of malignant disease. Spinal care, diagnostic evaluation, and the initiation of systemic therapy are crucial for outcomes in patients (pts) with advanced cancer. However, histopathology (HP) may be time consuming. The additional evaluation of spinal lesions using cytopathology (CP) has the potential to reduce the time to diagnosis (TTD) and time to therapy (TTT). CP and HP specimens from spinal lesions were evaluated in parallel in 61 pts (CP/HP group). Furthermore, 139 pts in whom only HP was performed were analyzed (HP group). We analyzed the TTD of CP and HP within the CP/HP group. Furthermore, we compared the TTD and TTT between the groups. The mean TTD in CP was 1.7 ± 1.7 days (d) and 8.4 ± 3.6 d in HP ( < 0.001). In 13 pts in the CP/HP group (24.1%), specific therapy was initiated based on the CP findings in combination with imaging and biomarker results before completion of HP. The mean TTT in the CP/HP group was 21.0 ± 15.8 d and was significantly shorter compared to the HP group (28.6 ± 23.3 d) ( = 0.034). Concurrent CP for MSLs significantly reduces the TTD and TTT. As a result, incorporating concurrent CP for analyzing spinal lesions suspected of malignancy might have the potential to enhance pts' quality of life and prognosis in advanced cancer. Therefore, we recommend implementing CP as a standard procedure for the evaluation of MSLs.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11083103 | PMC |
| http://dx.doi.org/10.3390/cancers16091659 | DOI Listing |
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