AI Article Synopsis
- The study explored the effectiveness of combining local proton irradiation with intra-tumoral injections of two types of bismuth nanoparticles (one coated with Pluronic-F127 and the other with Silane-PEG).
- Both types of nanoparticles significantly enhanced the antitumor effects of proton therapy when injected directly into the tumor, with greater effects observed at higher doses of nanoparticles and radiation.
- These findings suggest a potential new approach for improving treatments for malignant tumors by using nanoparticles to increase the efficacy of radiation therapy.
Article Abstract
We studied the antitumor activity of the combined use of local proton irradiation in two modes (10 and 31 Gy) with preliminary intra-tumoral injection of two types of bismuth nanoparticles differing in surface coating: coated with the amphiphilic molecule Pluronic-F127 or Silane-PEG (5 kDa)-COOH polymer. Nanoparticles were used in doses of 0.75 and 1.5 mg/mouse. In two independent series on experimental tumor model (solid Ehrlich carcinoma), bismuth nanoparticles of both modifications injected directly into the tumor enhanced the antitumor effects of proton therapy. Moreover, the radiosensitizing effect of bismuth nanoparticles administered via this route increased with the increasing the doses of nanoparticles and the doses of radiation exposure. In our opinion, these promising data obtained for the first time extend the possibilities of treating malignant neoplasms.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-024-06081-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!