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Penultimate proof for posterior occlusions: a commentary on "Focused update to guidelines for endovascular therapy for emergent large vessel occlusion: basilar artery occlusion patients".
J Neurointerv Surg
July 2024
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Structures and function of a tailoring oxidase in complex with a nonribosomal peptide synthetase module.
Nat Commun
January 2022
Department of Biochemistry, McGill University, Montréal, QC, H3G 0B1, Canada.
Nonribosomal peptide synthetases (NRPSs) are large modular enzymes that synthesize secondary metabolites and natural product therapeutics. Most NRPS biosynthetic pathways include an NRPS and additional proteins that introduce chemical modifications before, during or after assembly-line synthesis. The bacillamide biosynthetic pathway is a common, three-protein system, with a decarboxylase that prepares an NRPS substrate, an NRPS, and an oxidase.
View Article and Find Full Text PDFTowards enantioselective ultrahigh performance liquid chromatography-mass spectrometry-based metabolomics of branched-chain fatty acids and anteiso-fatty acids under reversed-phase conditions using sub-2-μm amylose- and cellulose-derived chiral stationary phases.
Chirality
March 2022
Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, University of Tübingen, Tübingen, Germany.
Branched-chain fatty acids (BCFAs) are mostly saturated fatty acids with one or more methyl, seldom ethyl, branches in the alkyl chain. They are derived from branched-chain amino acids, ruminant-derived food, or biosynthetic side products of acetyl-CoA carboxylase. They possess iso- (branching at penultimate carbon) and anteiso-fatty acid structure (branching at antepenultimate carbon) or are branched at any other position of the carbon chain.
View Article and Find Full Text PDFBuilding a Foundation for Precision Onco-Nutrition: Docosahexaenoic Acid and Breast Cancer.
Cancers (Basel)
December 2021
College of Medicine, Penn State University, Hershey, PA 17033, USA.
In vivo evidence of heterogeneous effects of n-3 fatty acids (N3FA) on cell signaling pathways associated with the reduced growth of breast cancer has been reported and is consistent with the expectation that N3FA will not exert uniform effects on all molecular subtypes of the disease. Similarly, available evidence indicates that many metabolites of N3FA are synthesized by mammalian cells and that they exert metabolite-specific biological activities. To begin to unravel the complex relationships among molecular subtypes and effects exerted by specific N3FA metabolites on those pathways, proof-of-concept experiments were conducted using cell lines representative of common molecular subtypes of human breast cancer.
View Article and Find Full Text PDFIR-783 Labeling of a Peptide Receptor for 'Turn-On' Fluorescence Based Sensing.
Chemosensors (Basel)
December 2018
Department of Bioengineering, University of Texas, Arlington, 500 UTA Blvd., Arlington, TX 76010, USA; (L.K.); (B.L.).
In this study, we examine a means for developing near-IR fluorescent sensors through streamlined, site-specific coupling with peptide-based receptors. As the penultimate step of solid-phase synthesis of a peptide-based receptor, we show a simple means of labeling the N' terminus with the near IR fluorophore IR-783 to afford a viable fluorescent sensor after cleavage from the resin. The proof-of-concept probe utilized a biotin mimetic peptide sequence as the receptive moiety.
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