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Equine common variable immunodeficiency: lessons from 100 clinical cases.
Equine Vet Educ
October 2024
Equine Immunology Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
The clinical manifestation of recurrent fevers and infections alerts the clinician to the possibility of an underlying immunodeficiency. Common variable immunodeficiency (CVID) in the horse is a rare late-onset, non-familial immunologic disorder of B cell depletion and/or dysfunction with resultant inadequate antibody production. The most common clinical presentations in horses with CVID are recurrent upper and/or lower respiratory infections, meningitis and/or ataxia, cholangiohepatitis, infectious colitis, infectious dermatitis, and severe gastrointestinal parasitism.
View Article and Find Full Text PDFOcrelizumab-induced organizing pneumonia in multiple sclerosis: case report and literature review.
Arch Clin Cases
July 2024
Division of Intensive Care Medicine and Pulmonary Medicine, Northwell Health, Port Jefferson, NY, USA.
Patients with relapsing-remitting multiple sclerosis should be offered disease-modifying therapies as part of their management. Recommended options include integrin antagonist therapy including natalizumab as well as anti-CD20 monoclonal antibodies like, ocrelizumab, rituximab, ofatumumab, and ublituximab. These therapies reduce relapse rates and slow brain lesion accumulation.
View Article and Find Full Text PDFCharacterization of a Novel Pathogenic PLCG2 Variant Leading to APLAID Syndrome Responsive to a TNF Inhibitor.
Arthritis Rheumatol
November 2024
The Second Affiliated Hospital, Zhejiang University School of Medicine and Liangzhu Laboratory, Zhejiang University, Hangzhou, China.
Article Synopsis
- - The study explores a novel variant of the PLCG2 gene (D993Y) linked to APLAID syndrome, a condition characterized by autoinflammation and immune dysregulation.
- - Using various advanced techniques, the researchers found that the D993Y mutation leads to heightened inflammatory responses and disruption of normal protein function in immune cells.
- - The findings highlight how this mutation activates several inflammatory pathways, contributing to the symptoms of APLAID syndrome and expanding the understanding of PLCγ2-related conditions.
Testing and Diagnosis of Clostridioides difficile Infection in Special Scenarios: A Systematic Review.
Cureus
April 2024
Gastroenterology and Hepatology, Frederick P. Whiddon College of Medicine at the University of South Alabama, Mobile, USA.
Introduction: infection (CDI) is a clinical and laboratory diagnosis. Populations at higher risk of developing disease require a high clinical index of suspicion for laboratory testing to avoid incorrect assumptions of colonization. Common risk factors include recent antibiotic use, elderly (>65 years old), and immunocompromised patients.
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