AI Article Synopsis
Article Abstract
Adipogenesis is one of the major mechanisms for adipose tissue expansion, during which spindle-shaped mesenchymal stem cells commit to the fate of adipocyte precursors and differentiate into round-shaped fat-laden adipocytes. Here, we investigated the lipidomic profile dynamics of ex vivo-differentiated brown and white adipocytes derived from the stromal vascular fractions of interscapular brown (iBAT) and inguinal white adipose tissues. We showed that sphingomyelin was specifically enriched in terminally differentiated brown adipocytes, but not white adipocytes. In line with this, freshly isolated adipocytes of iBAT showed higher sphingomyelin content than those of inguinal white adipose tissue. Upon cold exposure, sphingomyelin abundance in iBAT gradually decreased in parallel with reduced sphingomyelin synthase 1 protein levels. Cold-exposed animals treated with an inhibitor of sphingomyelin hydrolases failed to maintain core body temperature and showed reduced oxygen consumption and iBAT UCP1 levels. Conversely, blockade of sphingomyelin synthetic enzymes resulted in enhanced nonshivering thermogenesis, reflected by elevated body temperature and UCP1 levels. Taken together, our results uncovered a relation between sphingomyelin abundance and fine-tuning of UCP1-mediated nonshivering thermogenesis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11166878 | PMC |
| http://dx.doi.org/10.1016/j.jlr.2024.100559 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis.
Elife
December 2024
Shenzhen Key Laboratory of Systems Medicine for inflammatory diseases, School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Sun Yat-Sen University, Shenzhen, China.
The induction of adipose thermogenesis plays a critical role in maintaining body temperature and improving metabolic homeostasis to combat obesity. β3-adrenoceptor (β3-AR) is widely recognized as a canonical β-adrenergic G-protein-coupled receptor (GPCR) that plays a crucial role in mediating adipose thermogenesis in mice. Nonetheless, the limited expression of β3-AR in human adipocytes restricts its clinical application.
View Article and Find Full Text PDFField respirometry in a wild maternity colony of Bechstein's bats (Myotis bechsteinii) indicates higher metabolic costs above rather than below the thermoneutral zone.
J Exp Biol
December 2024
Applied Zoology and Nature Conservation, Zoological Institute and Museum, University of Greifswald, Loitzer Str. 26, 17489 Greifswald, Germany.
In a warming world, it is crucial to understand how rising temperature affects the physiology of organisms. To investigate the effect of a warming environment on the metabolism of heterothermic bats during the costly lactation period, we characterised metabolic rates in relation to roost temperature, the bats' thermoregulatory state (normothermia or torpor), time of day and age of juveniles. In a field experiment, we heated the communal roosts of a wild colony of Bechstein's bats (Myotis bechsteinii) every other day while measuring metabolic rates using flow-through respirometry.
View Article and Find Full Text PDFMDPAO1 Peptide from Human Milk Enhances Brown Adipose Tissue Thermogenesis and Mitigates Obesity.
Mol Cell Endocrinol
December 2024
Department of Pediatric Laboratory, Affiliated Children's Hospital of Jiangnan University, Wuxi, 214023, China. Electronic address:
The regulatory effect of breastfeeding on offspring metabolism has garnered significant attention as an effective strategy in combating childhood obesity. However, the underlying mechanism remains largely unknown. Through integrated analysis of multiple human milk peptide databases and functional screening, MDPAO1 (milk-derived peptide associated with obesity 1) was identified as having potential activity in promoting the expression of thermogenic genes.
View Article and Find Full Text PDFArousal-promoting effect of the parabrachial nucleus and the underlying mechanisms: Recent advances.
Prog Neuropsychopharmacol Biol Psychiatry
December 2024
Department of rehabilitation Medicine, SuiNing Central Hospital, The Affiliated Hospital of Chongqing Medical University, SuiNing 629000, China. Electronic address:
The parabrachial nucleus (PBN) is responsible for integrating both internal and external sensory information and controlling/regulating a wide range of physiological processes, such as feeding, thermogenesis, nociceptive and pruritic sensations, and respiration. Recently, the PBN has been found to be involved in mediating wakefulness maintenance, sleep-wake transition, exogenous neuromodulation of awakening, and arousal-promoting process triggered by drastic changes in the internal environments, such as hypercapnia, hypoxia, and hypertension. Multiple neural pathways and subpopulations of neurons are responsible for arousal-promoting effects of the PBN.
View Article and Find Full Text PDFMaternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis.
Ecotoxicol Environ Saf
December 2024
Nanjing Women and Children's Healthcare Institute, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China. Electronic address:
Background: Neonicotinoids (NEOs) are well-designed highly selective pesticides that target nicotinic acetylcholine receptors. However, their extensive use, accumulation, and biomagnification pose significant risks to humans. Increasing evidence has suggested that NEOs may affect glucose homeostasis, but little research has linked NEOs exposure to gestational diabetes mellitus (GDM), which is the most common disease in pregnancy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!