Here, we report a practical route to medicinally interesting lycorine congeners alongside formal syntheses of various lycorine-type natural products, including lycorine itself. The efficiency of our strategy derives from a back-to-back 5/6 radical cyclization sequence, which we systematically studied both experimentally and computationally. The results of our work will facilitate future development of urgently needed antiviral therapeutics based on lycorine.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.4c01271 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nucleophilicity at copper(-I) in a compound with a Cu-Mg bond.
Nat Commun
January 2025
Department of Chemistry, University of Bath, Bath, BA2 7AY, UK.
Copper is ubiquitous as a structural material, and as a reagent in (bio)chemical transformations. A vast number of chemical reactions rely on the near-inevitable preference of copper for positive oxidation states to make useful compounds. Here we show this electronic paradigm can be subverted in a stable compound with a copper-magnesium bond, which conforms to the formal oxidation state of Cu(-I).
View Article and Find Full Text PDFEnablers and inhibitors of nursing and midwifery leadership in Pacific Island collectivist cultures.
Int Nurs Rev
March 2025
WHO Collaborating Centre on Nursing Midwifery & Health Development, University of Technology Sydney, Sydney, New South Wales, Australia.
Aim: To identify and explore inhibitors and enablers of nursing and midwifery leadership in the Pacific; to develop context-specific recommendations for policy and practice.
Background: Many Pacific Island countries experience poor health outcomes and are vulnerable to climate-related health emergencies. Nursing and midwifery leadership is essential to improve regional health outcomes through influencing policy decisions, strengthening health systems and ensuring optimal health workforce utilisation.
Strain-release trifluoromethoxylation and pentafluorosulfanoxylation of [1.1.0]bicyclobutanes: expanded access to fluorinated cyclobutane hybrid bioisosteres.
Chem Commun (Camb)
January 2025
Department of Chemistry, University of California, Davis, 1 Shields Ave., Davis, CA 95616, USA.
Methods for formal bromo-trifluoromethoxylation and bromo-pentafluorosulfanoxylation of [1.1.0]bicyclobutanes using AgOCF or AgOSF and 1,3-dibromo-5,5-dimethylhydantoin are disclosed.
View Article and Find Full Text PDFBiomarkers and Social Determinants in atherosclerotic Arterial Diseases: A Scoping Review.
Ann Vasc Surg
January 2025
Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, 88100, Catanzaro, Italy; Interuniversity Center of Phlebolymphology (CIFL), "Magna Graecia" University, 88100 Catanzaro, Italy. Electronic address:
Background: Arterial diseases like coronary artery disease, carotid stenosis, peripheral artery disease, and abdominal aortic aneurysm have high morbidity and mortality, making them key research areas. Their multifactorial nature complicates patient treatment and prevention. Biomarkers offer insights into the biochemical and molecular processes, while social factors also significantly impact patients' health and quality of life.
View Article and Find Full Text PDFNovel isoxazole thiophene-containing compounds active against Mycobacterium tuberculosis.
Bioorg Med Chem Lett
January 2025
Calibr-Skaggs Institute for Innovative Medicines, a division of Scripps Research, La Jolla, CA 92037, United States. Electronic address:
Screening of the ChemDiv molecular library in cholesterol media against Mycobacterium tuberculosis (Mtb) H37Rv strain identified a novel isoxazole thiophene hit as a putative Rv1625c/Cya activator with a promising in vitro activity and good pharmacokinetic properties. Twenty-nine analogs were synthesized to assess the structure-activity relationships (SAR) to further improve potency. The most notable analog was P15, which showed an intramacrophage EC = 1.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!