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Side effects of COVID-19 vaccines among Iranian healthcare workers: a retrospective cohort study. | LitMetric

AI Article Synopsis

  • This study examined the incidence and severity of side effects from COVID-19 vaccinations among healthcare workers in Iran from March to June 2021.
  • Researchers found that over half (55.85%) of the 42,018 participants reported side effects, with factors like gender, education level, comorbidities, and vaccine type influencing the risk and severity.
  • Overall, while side effects were common, especially with certain vaccines, the study concluded that the benefits of vaccination significantly outweigh the risks, particularly for high-risk groups.

Article Abstract

Introduction: This study assessed the incidence and severity of side effects associated with coronavirus disease 2019 (COVID-19) vaccination among healthcare workers registered with the Medical Council of the Islamic Republic of Iran.

Methodology: A retrospective cohort study was conducted on the healthcare workers focusing on the side-effects of COVID-19 vaccines from March to June 2021. Data were collected using online questionnaires. Multivariable logistic regression was used to assess the association between side effects of the vaccines and demographic variables, comorbidities, vaccine type, and history of COVID-19.

Results: Out of 42,018 people who were included, 55.85% reported at least one side effect after receiving the first vaccine dose. 4.59% of those with side effects sought diagnostic intervention or were referred to treatment centers. Multivariable logistic regression indicated that being a woman, higher education, having a history of COVID-19 infection, and having comorbidities increased the risk of side effects. The AstraZeneca vaccine significantly increased the risk of side effects compared to the Sputnik vaccine, while the Sinopharm vaccine decreased this risk. The risk of developing a side effect decreased with age. The risk of moderate and severe side effects was significantly associated with gender, younger age, comorbidities, and a history of COVID-19 infection. Moderate and severe side effects were less reported by those who received the Sinopharm vaccine.

Conclusions: Clinical complications after COVID-19 vaccination, directly or indirectly caused by the vaccines, are common. However, the benefits of COVID-19 vaccines greatly outweigh the risk of reversible side effects, especially among the high-risk population.

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Source
http://dx.doi.org/10.3855/jidc.17691DOI Listing

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