AI Article Synopsis
- - The CAIDE risk score is a predictor of dementia risk, but its relationship with Alzheimer's disease pathology is not well-studied.
- - A study involving 600 cognitively normal participants found that a higher CAIDE score correlates with increased tau-related AD biomarkers and lower cognitive performance on tests like the MMSE and MoCA.
- - The findings suggest that tau pathology mediates the effect of the CAIDE score on cognitive performance, indicating that higher dementia risk may contribute to cognitive decline through neurodegeneration.
Article Abstract
Background: Cardiovascular Risk Factors, Ageing and Dementia (CAIDE) risk score serves as a credible predictor of an individual's risk of dementia. However, studies on the link of the CAIDE score to Alzheimer's disease (AD) pathology are scarce.
Objective: To explore the links of CAIDE score to cerebrospinal fluid (CSF) biomarkers of AD as well as to cognitive performance.
Methods: In the Chinese Alzheimer's Biomarker and LifestylE (CABLE) study, we recruited 600 cognitively normal participants. Correlations between the CAIDE score and CSF biomarkers of AD as well as cognitive performance were probed through multiple linear regression models. Whether the correlation between CAIDE score and cognitive performance was mediated by AD pathology was researched by means of mediation analyses.
Results: Linear regression analyses illustrated that CAIDE score was positively associated with tau-related biomarkers, including pTau (p < 0.001), tTau (p < 0.001), as well as tTau/Aβ42 (p = 0.008), while it was in negative association with cognitive scores, consisting of MMSE score (p < 0.001) as well as MoCA score (p < 0.001). The correlation from CAIDE score to cognitive scores was in part mediated by tau pathology, with a mediation rate varying from 3.2% to 13.2%.
Conclusions: A higher CAIDE score, as demonstrated in our study, was linked to more severe tau pathology and poorer cognitive performance, and tau pathology mediated the link of CAIDE score to cognitive performance. Increased dementia risk will lead to cognitive decline through aggravating neurodegeneration.
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| http://dx.doi.org/10.3233/JAD-240005 | DOI Listing |
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