AI Article Synopsis
Article Abstract
Dilution of human serum or solutions of highly purified subcomponent C1q of human complement results in the drop of C1q activity. Electron microscopy of highly purified subcomponent C1q revealed that a certain part of molecules has a changed ultrastructure and C1q subunits are dissociated. As the preparations for electron microscopy have been obtained from dilute solutions, the changes in the ultrastructure and C1q inactivation should be interrelated phenomena. The conformational liability of the C1q structure is supposed to have a functional role.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Neuroprotective role of sialic-acid-binding immunoglobulin-like lectin-11 in humanized transgenic mice.
Front Neurosci
December 2024
Institute of Reconstructive Neurobiology, Medical Faculty and University Hospital of Bonn, University of Bonn, Bonn, Germany.
Brain aging is a chronic process linked to inflammation, microglial activation, and oxidative damage, which can ultimately lead to neuronal loss. Sialic acid-binding immunoglobulin-like lectin-11 (SIGLEC-11) is a human lineage-specific microglial cell surface receptor that recognizes -2-8-linked oligo-/polysialylated glycomolecules with inhibitory effects on the microglial inflammatory pathways. Recently, the gene locus was prioritized as a top tier microglial gene with potential causality to Alzheimer's disease, although its role in inflammation and neurodegeneration remains poorly understood.
View Article and Find Full Text PDFA new player in the game: identification of C1ql1 as a novel factor driving OPC differentiation.
FEBS J
January 2025
Department of Immunology and Infection, NIC&R Lab, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Oligodendrocytes (OLGs) are the myelin-producing cells in the central nervous system (CNS). Following injury, these cells are prone to death, leading to demyelination and, eventually, axonal loss and neurodegeneration. Upon injury, the damaged CNS repopulates the lesion with oligodendrocyte precursor cells (OPCs) that consequently mature into OLGs to repair the myelin damage and prevent further axonal loss.
View Article and Find Full Text PDFSerum proteomic changes related to residual impairment in remittent depression are associated with immune and inflammatory processes.
Sci Rep
October 2024
Department of Biomedical Laboratory Science, Graduate School, Eulji University, Uijeongbu, 11759, Republic of Korea.
In patients with major depressive disorder, various functional areas are impaired, negatively impacting the quality of life. Remission can restore pre-depression functions; however, some patients may still have residual impairments. Distinguishing between near-normal recovery and residual impairment helps identify those at a high risk of relapse risk and helps tailor treatment.
View Article and Find Full Text PDFFirst-Trimester Preeclampsia-Induced Disturbance in Maternal Blood Serum Proteome: A Pilot Study.
Int J Mol Sci
October 2024
V.I. Kulakov National Medical Research Center for Obstetrics Gynecology and Perinatology, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia.
Article Synopsis
- Preeclampsia (PE) is a serious pregnancy condition affecting up to 5% of pregnant women, leading to significant health risks for both mothers and newborns, with a need for better early risk assessment methods.
- A study identified ten maternal serum proteins as potential early markers for PE at 11-13 weeks gestation, with most of these proteins having connections to PE from previous research.
- A Support Vector Machine (SVM) model using 19 proteins showed a high predictive power (AUC of 0.91, 87% sensitivity, 95% specificity) for early PE detection, outperforming standard screening methods.
C1ql1 expression in oligodendrocyte progenitor cells promotes oligodendrocyte differentiation.
FEBS J
January 2025
Department of Neuroscience, University of Connecticut Health, Farmington, CT, USA.
Myelinating oligodendrocytes arise from the stepwise differentiation of oligodendrocyte progenitor cells (OPCs). Approximately 5% of all adult brain cells are OPCs. Why would a mature brain need such a large number of OPCs? New myelination is possibly required for higher-order functions such as cognition and learning.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!