Autotaxin, encoded by the gene, produces lysophosphatidic acid (LPA), which exerts numerous biological functions via its cognate receptors. null mutant mice die by embryonic day 9.5 owing to aberrant vascular development in the yolk sac, preventing analysis after that period. In this study, we found that heterozygous mice in the DBA/2 genetic background showed an eye-open-at-birth phenotype at high frequency, caused by failure of eyelid closure during the embryonic stage. Notably, wildtype pups from the heterozygous dam showed the phenotype, although at lower frequency, suggesting that maternal LPA affects the embryonic development.
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| http://dx.doi.org/10.17912/micropub.biology.001212 | DOI Listing |
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