AI Article Synopsis
- Human adenoviruses (HAdVs) are recognized as a significant cause of gastroenteritis in children, but comprehensive global data on their prevalence has been lacking.
- A systematic search from 2003 to 2023 revealed an estimated global prevalence of HAdV infection at 10%, with the highest rates found in Africa and among children under 5 years old, specifically in hospitalized patients.
- The findings highlight the role of HAdVs in pediatric gastroenteritis and suggest the need for preventive strategies and vaccine development to address this issue.
Article Abstract
Purpose: Human adenoviruses (HAdVs) have always been suggested as one of the main causes of gastroenteritis in children. However, no comprehensive report on the global epidemiology of these viruses in pediatric gastroenteritis is available.
Methods: A systematic search was conducted to obtain published papers from 2003 to 2023 in three main databases PubMed, Scopus, and Web of Science.
Results: The estimated global pooled prevalence of HAdV infection in children with gastroenteritis was 10% (95% CI: 9-11%), with a growing trend after 2010. The highest prevalence was observed in Africa (20%, 95% CI: 14-26%). The prevalence was higher in inpatients (11%; 95% CI: 8-13%) and patients aged 5 years old and younger (9%; 95% CI: 7-10%). However, no significant difference was observed between male and female patients (P = 0.63). The most prevalent species was found to be the species F (57%; 95% CI: 41-72%). The most common HAdVs observed in children with gastroenteritis were types 40/41, 38, and 2. Analysis of case-control studies showed an association between HAdV and gastroenteritis in children (OR: 2.28, 95% CI; 1.51-3.44).
Conclusion: This study provided valuable insights into the importance of HAdVs in children with gastroenteritis, especially in hospitalized and younger children. The results can be used in future preventive measurements and the development of effective vaccines.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11084101 | PMC |
| http://dx.doi.org/10.1186/s12879-024-09386-x | DOI Listing |
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