AI Article Synopsis
- - The study analyzed the intestinal microbiota diversity among adolescents with obesity and those with normal weight, focusing on different ethnic groups, specifically Russians and Buryats.
- - Researchers utilized metasequencing of the 16S rRNA gene to evaluate alpha diversity using several statistical indices, revealing significant differences in microbiota between the groups studied.
- - Findings suggest that alpha diversity indices are useful for assessing variations in intestinal microbiota linked to complex conditions like adolescent obesity, although careful consideration of their application is necessary.
Article Abstract
We compared alpha diversity indices of the intestinal microbiota in adolescents with obesity and normal body weight, taking into account their ethnicity. Intestinal biocenosis was studied by metasequencing of amplicon libraries of V3-V4 fragments of the 16S rRNA gene. The alpha diversity of the microbiota was assessed using classical and alternative indices. Statistically significant differences in intestinal microbiota were observed between Russians with obesity and Buryats with normal body weight, as well as between Russians with obesity and Buryats with obesity when assessing the Shannon-Weaver, Chao1 indices, Faith phylogenetic diversity index, ACE, Fisher, Gini coefficient, Margalef, and Menkhinik indices. It was shown that alpha diversity indices can be used to assess significance of differences and variability of the intestinal microbiota in multifactorial diseases such as obesity in adolescents; however, the scope of application of the criteria should be considered.
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| http://dx.doi.org/10.1007/s10517-024-06073-4 | DOI Listing |
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