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Crosstalk between circadian clocks and pathogen niche. | LitMetric

Crosstalk between circadian clocks and pathogen niche.

PLoS Pathog

Berkeley Public Health, Molecular and Cell Biology Department, University of California Berkeley, Berkeley, California, United States of America.

Published: May 2024

AI Article Synopsis

Article Abstract

Circadian rhythms are intrinsic 24-hour oscillations found in nearly all life forms. They orchestrate key physiological and behavioral processes, allowing anticipation and response to daily environmental changes. These rhythms manifest across entire organisms, in various organs, and through intricate molecular feedback loops that govern cellular oscillations. Recent studies describe circadian regulation of pathogens, including parasites, bacteria, viruses, and fungi, some of which have their own circadian rhythms while others are influenced by the rhythmic environment of hosts. Pathogens target specific tissues and organs within the host to optimize their replication. Diverse cellular compositions and the interplay among various cell types create unique microenvironments in different tissues, and distinctive organs have unique circadian biology. Hence, residing pathogens are exposed to cyclic conditions, which can profoundly impact host-pathogen interactions. This review explores the influence of circadian rhythms and mammalian tissue-specific interactions on the dynamics of pathogen-host relationships. Overall, this demonstrates the intricate interplay between the body's internal timekeeping system and its susceptibility to pathogens, which has implications for the future of infectious disease research and treatment.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11081299PMC
http://dx.doi.org/10.1371/journal.ppat.1012157DOI Listing

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