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Adipocyte sphingosine kinase 1 regulates histone modifiers to disrupt circadian function.
bioRxiv
September 2024
Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA.
Circadian rhythms align biological functions with the 24-hour day-night cycle, but modern artificial light disrupts these patterns, contributing to health issues like obesity and cardiovascular disease. The circadian clock operates through a transcriptional-translational feedback loop involving core components such as BMAL1 and CLOCK. Recent research has shown circadian variations in sphingolipid metabolism, specifically sphingosine-1-phosphate (S1P), which plays crucial signaling roles.
View Article and Find Full Text PDFCircadian-Regulated GR Signaling Mediates Morning Arrhythmias.
Circ Res
May 2024
Department of Physiology and Pathophysiology (I.R.-N., M.C., L.A.K.), Max Rady Faculty of Health Sciences, The Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Rady College of Medicine, University of Manitoba, Winnipeg, Canada.
Unlabelled: Adaptive immune cells are regulated by circadian rhythms (CR) under both steady state conditions and during responses to infection. Cytolytic CD8 T cells display variable responses to infection depending upon the time of day of exposure. However, the neuronal signals that entrain these cyclic behaviors remain unknown.
View Article and Find Full Text PDFA systematic review of chronobiology for neonatal care units: What we know and what we should consider.
Sleep Med Rev
February 2024
Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research, University Hospital of Cologne, Cologne, Germany.
A Cochrane 2016 review indicated cycled light might benefit neonatal health in hospital. We systematically reviewed chronobiological factors for neonatal health in hospital units, identifying 56 relevant studies on light-dark cycles, feeding, noise, massage therapy, rooming-in, incubators vs. cribs, neonatal units vs.
View Article and Find Full Text PDFAstrocytic control of extracellular GABA drives circadian timekeeping in the suprachiasmatic nucleus.
Proc Natl Acad Sci U S A
May 2023
Neurobiology Division, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
The hypothalamic suprachiasmatic nucleus (SCN) is the master mammalian circadian clock. Its cell-autonomous timing mechanism, a transcriptional/translational feedback loop (TTFL), drives daily peaks of neuronal electrical activity, which in turn control circadian behavior. Intercellular signals, mediated by neuropeptides, synchronize and amplify TTFL and electrical rhythms across the circuit.
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