Incidence of statin-associated muscle symptoms in patients taking statins with or variants.

Statins are commonly used medications. Variants in , , and are known predictors of muscle effects when taking statins. More exploratory genes include and , which can also be associated with disease conditions. Patients with pathogenic/likely pathogenic variants in or were identified through an elective genomic testing program. Through chart review, patients with a history of statin use were assessed for statin-associated muscle symptoms (SAMS) along with collection of demographics and other known risk factors for SAMS. Of the 23 patients who had a pathogenic or likely pathogenic or variant found, 12 had previous statin use; of these, SAMS were identified in four patients. These data contribute to previous literature suggesting patients with variants may have an increased SAMS risk. Additional research will be helpful in further investigating this relationship and providing recommendations.