AI Article Synopsis
- Significant research is focused on identifying genomic variations that relate to cancer susceptibility, particularly in noncoding DNA and epigenetic changes.
- Noncoding regions play a crucial role in regulating genes, which can affect how cancer develops, but require advanced methods for thorough investigation.
- Future studies will explore specific areas within noncoding DNA, like pseudoexons and promoter variants, harnessing new technologies and bioinformatics to better understand their impact on cancer.
Article Abstract
Exhaustive efforts have been dedicated to uncovering genomic aberrations linked to cancer susceptibility. Noncoding sequence variants and epigenetic alterations significantly influence gene regulation and could contribute to cancer development. However, exploring noncoding regions in hereditary cancer susceptibility demands cutting-edge methodologies for functionally characterizing genomic discoveries. Additionally, comprehending the impact on cancer development of variants in noncoding DNA and the epigenome necessitates integrating diverse data through bioinformatic analyses. As novel technologies and analytical methods continue to advance, this realm of research is rapidly gaining traction. Within this mini-review, we delve into future research domains concerning aberrations in noncoding DNA regions, such as pseudoexons, promoter variants and -epimutations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318707 | PMC |
| http://dx.doi.org/10.2217/fon-2023-0665 | DOI Listing |
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