Livedoid vasculopathy (LV) can be a challenging diagnosis with an interesting pathophysiology. LV is an uncommon diagnosis that can be easily mistaken for more common skin conditions, especially in a person of color who may be underrepresented in pathology images used in medical education. LV has an average of five years from initial presentation to diagnosis, possibly due to providers not having it on their differential for lower extremity ulcerations. Prolonged time to diagnosis can potentially lead to life-changing complications. We present a case of a former professional sprinter who became debilitated by neuropathy secondary to complications from LV. He was seen multiple times and had an extensive work-up exploring a broad differential including autoimmune etiologies, hypercoagulable disorders, neuropathies, and other vascular disorders before reaching the diagnosis. This case emphasizes the importance of early diagnosis and treatment with a multidisciplinary team to help prevent the progression of these symptoms. We break down an extensive work-up that involves a multidisciplinary team including dermatology, hematology, neurology, rheumatology, and vascular surgery. This case will also highlight examples of LV in a patient with a dark skin complexion, which can be challenging to find in current literature. We additionally show images that demonstrate many of the classic pathologic findings associated with LV and how those can help lead to the diagnosis along with detailed descriptions of those findings. Classic physical exam findings including atrophic blanche and lower extremity ulcerations are highlighted. We also review LV's history, diagnosis, and treatment to help readers achieve a better understanding of the disease.
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http://dx.doi.org/10.7759/cureus.57812 | DOI Listing |
JAAD Case Rep
January 2025
Department of Dermatology, National University Hospital, Singapore, Singapore.
Int J Rheum Dis
December 2024
Department of Rheumatology of Lucania-UOSD of Rheumatology, "Madonna delle Grazie" Hospital, Matera, Italy.
A 58-year-old female smoker diagnosed with myelodysplastic syndrome (MDS) presented with Raynaud's phenomenon and a "scleroderma-like" pattern on nailfold capillaroscopy. The capillaroscopic abnormalities were observed across all fingers, including those without clinical manifestations of onychomycosis. Over a two-year follow-up, there was no evidence of clinical or serological progression toward a connective tissue disease, particularly systemic sclerosis.
View Article and Find Full Text PDFAnn Hematol
December 2024
Division of Hematology, Department of Medicine, UNC Chapel Hill School of Medicine, Chapel Hill, NC, United States of America.
Chronic leg ulceration is a debilitating manifestation of hemoglobinopathies, and best management is uncertain. Livedoid vasculopathy (LV) is a cutaneous non-inflammatory thrombotic vasculopathy treated with anticoagulation that has been identified in hemoglobinopathy-associated chronic leg ulceration. However, most patients with hemoglobinopathy-associated ulcers do not undergo workup for secondary causes, and the prevalence and relevance of LV is unclear.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Hand Surgery, Department of Orthopedics, Qilu Hospital of Shandong University, #107 Wenhua Xilu, Jinan, China.
Cureus
October 2024
Internal Medicine, Veterans Affairs Caribbean Healthcare System, San Juan, PRI.
Livedoid vasculopathy (LV) is a rare vascular disorder characterized by excessive thrombosis of cutaneous vasculature, leading to dermal vessel occlusion, skin hypoxia, and ulceration. The nonspecific nature of its clinical manifestations often complicates diagnosis and inadequate oxygenation results in lesions that take longer to heal and are more susceptible to infections and complications. Despite its impact on patient quality of life, LV remains largely undocumented in the literature, making effective management challenging.
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