AI Article Synopsis

  • Cystoscopy is the standard method for monitoring non-muscle invasive bladder cancer (NMIBC), but it is invasive and not always accurate.
  • This study explored using urine tumor DNA (utDNA) analysis as a less invasive alternative, following 47 patients over two years and employing BladMetrix DNA methylation tests during cystoscopy appointments.
  • The results showed that utDNA detected 91% of recurrences, allowed for a 55% reduction in cystoscopies needed, and identified 48% of recurrences earlier than cystoscopy, indicating that utDNA could help personalize and improve surveillance for bladder cancer.

Article Abstract

Cystoscopy is the gold standard for surveillance of non-muscle invasive bladder cancer (NMIBC), but the procedure is invasive and has suboptimal accuracy. The aim of this study was to investigate the potential of analyzing urine samples for the presence of urine tumor DNA (utDNA) to replace cystoscopy for surveillance of bladder cancer recurrence. In this longitudinal, prospective, and observational study, 47 patients were followed for recurrence for 2 years, involving analysis of utDNA using the BladMetrix DNA methylation biomarker test at each cystoscopy. In total, utDNA was detected in 21/23 recurrences (91% sensitivity), including 5/5 T1, T2, and carcinoma in situ (CIS) tumors (100%) and 10/12 Ta tumors (83%), with < 1% false-negative test results. Importantly, utDNA analysis showed the potential to reduce the number of cystoscopies by 55%, benefitting 79% of the patients. Eleven of 23 recurrences (48%) were detected earlier with utDNA than with cystoscopy, and distinct patterns of residual utDNA post-surgery indicated minimal residual disease (MRD) or field effect in 6% and 15% of the patients, respectively. In conclusion, utDNA analysis shows high sensitivity to detect tumor recurrence, potential to reduce the number of cystoscopies, and promise to guide patient-specific surveillance regimens.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11547231PMC
http://dx.doi.org/10.1002/1878-0261.13639DOI Listing

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