AI Article Synopsis
- Three new liposidomycin compounds (1, 2, and 4) were identified from the culture of a specific Streptomyces bacteria as potential treatments against Mycobacterium avium complex infections.
- The chemical structures of all liposidomycins, including new and known variants, were determined using techniques like NMR and MS analysis.
- The compounds demonstrated varying levels of effectiveness against M. avium and M. intracellulare, with minimal inhibitory concentrations (MIC) ranging from 2.0 to 64 μg/ml, and showed promising results in a silkworm infection model.
Article Abstract
Three new liposidomycin congeners (1, 2, and 4), together with 14 known liposidomycins (3 and 5-17), were isolated from the culture broth of Streptomyces sp. TMPU-20A065 as anti-Mycobacterium avium complex agents. The structures of liposidomycins were elucidated by spectroscopic analyses, including NMR and MS. Compounds 1, 2, and 4 belong to type-I liposidomycin-containing sulfate groups and methylglutaric acid, each with a different acyl side chain in the structure. Compounds 1-17 exhibited in vitro anti-M. avium and M. intracellulare activities with MIC values ranging between 2.0 and 64 μg ml. Furthermore, 1-17 exerted potent therapeutic effects in an in vivo-mimic silkworm infection model with ED values ranging between 0.12 and 3.7 μg larva g.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208132 | PMC |
| http://dx.doi.org/10.1038/s41429-024-00724-4 | DOI Listing |
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New liposidomycin congeners produced by Streptomyces sp. TMPU-20A065, anti-Mycobacterium avium complex agents with therapeutic efficacy in a silkworm infection model.
J Antibiot (Tokyo)
July 2024
Division of Natural Product Chemistry, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi, 981-8558, Japan.
Article Synopsis
- Three new liposidomycin compounds (1, 2, and 4) were identified from the culture of a specific Streptomyces bacteria as potential treatments against Mycobacterium avium complex infections.
- The chemical structures of all liposidomycins, including new and known variants, were determined using techniques like NMR and MS analysis.
- The compounds demonstrated varying levels of effectiveness against M. avium and M. intracellulare, with minimal inhibitory concentrations (MIC) ranging from 2.0 to 64 μg/ml, and showed promising results in a silkworm infection model.
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