AI Article Synopsis
- Oxaliplatin (OX) is linked to a condition called porto-sinusoidal vascular disorder (PSVD) in patients with colon cancer, and the study aimed to understand its natural progression and identify risk factors.
- A multicenter study compared patients with PSVD due to OX treatment to controls without PSVD, looking at various data points and genetic markers.
- The study found that an increase in spleen diameter was the strongest predictor of PSVD, and patients with low platelet counts a year after treatment faced a higher risk, suggesting they should be monitored for related complications.
Article Abstract
Background And Aims: Oxaliplatin (OX) has been described as a potential etiologic agent for porto-sinusoidal vascular disorder (PSVD). Our aim was to describe the natural history of PSVD due to OX in colon cancer (CRC) and identify risk factors for its development.
Methods: We made a multicenter retrospective case-control (ratio 1:3) study with patients diagnosed of PSVD-OX. Baseline data, end of treatment, years of follow-up and diagnosis of PSVD were collected and compared to controls (without PSVD). Besides, 16 different SNPs were selected from bibliography and analyzed by genotyping in the case group to identify potential genetic risk factors.
Results: 41 cases were identified, with a median time to PSVD diagnosis after the end of OX of 34 months. Spleen diameter was the strongest predictor of PSVD during treatment (OR 43.94 (14.48-133.336); p < 0.0001). Additionally, thrombocytopenia (<150 × 10^9) at one year was a significant disease risk marker (OR 9.35; 95% CI: 3.71-23.58; p = 0.001). We could not establish any significant association between the selected SNPs and PSVD diagnosis.
Conclusion: The increase of spleen diameter is the strongest predictor of PSVD in patients treated with OX for CRC. These patients could be candidates for a specific follow-up of portal hypertension-related complications.
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| http://dx.doi.org/10.1016/j.dld.2024.04.010 | DOI Listing |
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