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Philip S Hench and the discovery of cortisone.
Ann Rheum Dis
May 2024
Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.
What is the impact of sex hormones on the pathogenesis of rheumatoid arthritis?
Front Med (Lausanne)
July 2022
Centre for Rheumatology, Department of Inflammation, Division of Medicine, University College London, London, United Kingdom.
Rheumatoid arthritis (RA) is the most common inflammatory rheumatic disease and has a female predominance of around 3:1. The relationship between sex hormones and RA has been of great interest to researchers ever since Philip Hench's observations in the 1930's regarding spontaneous disease amelioration in pregnancy. Extensive basic scientific work has demonstrated the immunomodulatory actions of sex hormones but this therapeutic potential has not to date resulted in successful clinical trials in RA.
View Article and Find Full Text PDFMechanisms determining the amelioration of rheumatoid arthritis in pregnancy: A systematic review.
Semin Arthritis Rheum
December 2020
Rayne Institute, University College London Centre for Rheumatology Research, University Street, London WC1E 6JF, United Kingdom. Electronic address:
Background: The phenomenon of pregnancy-induced remission of rheumatoid arthritis (RA) was first reported by Philip Hench in 1938. Despite extensive efforts, the underlying scientific basis has remained elusive. A number of different potential mechanisms have been investigated.
View Article and Find Full Text PDFLost in Translation? Cortisone and the Treatment of Rheumatoid Arthritis in Britain, 1950-1960. [corrected].
Hist Philos Life Sci
November 2019
Centre for the History of Science, Technology and Medicine (CHSTM), Simon Building, University of Manchester, Manchester, M13 9PL, UK.
Cortisone, initially known as 'compound E' was the medical sensation of the late 1940s and early 1950s. As early as April 1949, only a week after Philip Hench and colleagues first described the potential of 'compound E' at a Mayo Clinic seminar, the New York Times reported the drug's promise as a 'modern miracle' in the treatment of rheumatoid arthritis (RA). Given its high profile, it is unsurprising that historians of medicine have been attracted to study the innovation of cortisone.
View Article and Find Full Text PDFCortisone in Popular Culture: Roueché, Ray, and Hench.
Mayo Clin Proc Innov Qual Outcomes
June 2019
Department of Development, Mayo Clinic, Rochester, MN.
In this article, the authors offer a new perspective on how the administration of Compound E (ie, cortisone) to a volunteer Mayo Clinic patient with rheumatoid arthritis and the patient's subsequent miraculous improvement led not only to a major, successful clinical trial but also a Nobel Prize. The early and late side effects as an undesirable outcome of treatment of corticosteroids would soon follow. Corticosteroid side effects became known in popular culture, first through an indepth article in by medical journalist Berton Roueché, and later through a major fiction film, , directed by Nicholas Ray.
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