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Etomidate and its derivatives: time to say goodbye?
Br J Anaesth
January 2025
Universitätsmedizin Göttingen, Göttingen, Germany.
Etomidate, an intravenous hypnotic used for anaesthesia and critical care, is known for its undesirable side effects, including pain on injection, myoclonus, and adrenocortical depression. Despite its continued clinical use because of its haemodynamic stability and rapid onset and offset of effect, alternatives like propofol, ketamine, and remimazolam offer fewer drawbacks. Recent efforts to improve etomidate through chemical modifications, such as methoxyethyl etomidate hydrochloride (ET-26), have shown limited success, with persistent issues like involuntary muscle movements and adrenocortical suppression.
View Article and Find Full Text PDFHow bereaved families conceptualise good care and communication in intensive care in South Australia.
BMC Health Serv Res
December 2024
Intensive Care Unit, Royal Adelaide Hospital, Adelaide, Australia.
Since 2018, DonateLife South Australia and the Royal Adelaide Hospital (RAH) have collaborated to deliver routine family follow-up after bereavement in the intensive care unit (ICU). This follow-up includes a telephone interview that invites bereaved family members to comment on the quality of care and communication experienced in the ICU. To identify bereaved families' experiences, including how they conceptualise good care and communication in intensive care, an analysis was conducted on all qualitative data collected during 118 interviews completed between 1 February 2018 and 30 May 2019.
View Article and Find Full Text PDF"I was surprised that the veins were the cause" - The illness trajectory of people with venous leg ulcers: A qualitative study.
J Tissue Viability
December 2024
Institute of Nursing Science, Department Public Health, University of Basel, Basel, Switzerland; Practice Development and Research Department, University Hospital Basel, Basel, Switzerland. Electronic address:
Background: Patients with venous leg ulcers (VLUs) often carry out inadequate self-care. Person-centered care is recommended as effective support. Understanding the illness trajectory from the patient's perspective could be a way to better understand patients' needs.
View Article and Find Full Text PDFTo be frank: is it time to say goodbye to Abbe-McIndoe and Vecchietti?
Fertil Steril
December 2024
Division of Reproductive Endocrinology and Infertility, OB/GYN and Women's Health Institute, Cleveland Clinic Foundation, Cleveland, Ohio.
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