Introduction: Traumatic spinal cord injury (tSCI) is a devastating event that can cause permanent loss of function or disability. Time to surgical decompression of the spinal cord affects outcomes and is a critical principle in management of tSCI. One of the major determinants of time to decompression is transport time. To date, no study has compared the neurological outcomes of tSCI patients transported via ground/ambulance versus air/helicopter.
Objective: This retrospective cohort study sought to assess the association of the mode of transport on the neurological outcomes of tSCI patients.
Methods: Data from 46 ground transport and 29 air transport patients with tSCI requiring surgical decompression were collected. Outcomes were assessed by the change in American Spinal Injury Association Impairment Scale (AIS) grade from admission to discharge. Additionally, the utilization of air versus ground transport was assessed based on the distance from the admitting institution.
Results: Among the transport groups, there were no significant differences (P < 0.05) in patient demographics. Helicopter transport patients demonstrated higher rates of AIS grade improvement ( = 0.004), especially among AIS grade A/grade B patients ( = 0.02; = 0.02, respectively), compared to the ambulance transport group. Additionally, within the cohort of patients undergoing decompression within 0 to 12 hours, helicopter transport was associated with higher AIS grade improvement ( = 0.04) versus the ambulance transport group. Helicopter transport was used more frequently at distances greater than 80 miles from the admitting institution ( = 0.01).
Conclusions: This study suggests that helicopter transport of tSCI patients requiring surgical decompression was associated with improved neurological outcomes compared to patients transported via ambulance.
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World Neurosurg
December 2024
Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address:
J Pediatr Surg
December 2024
Children's Hospital New Orleans, Department of Surgery, New Orleans LA 70118, USA; Louisiana State University Health Sciences Center, Department of Surgery, Division of Pediatric Surgery, New Orleans LA 70112, USA. Electronic address:
Introduction: Traumatic injury is the leading cause of pediatric mortality and morbidity in the United States. While behavioral impairments of children after traumatic brain injury (TBI) have been described, outcomes following traumatic spinal cord injury (SCI) and multi-trauma (MT) are less known. We aimed to address the prevalence of behavioral and neuropsychiatric disorders in pediatric and adolescent trauma patients.
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Laboratory of Nuclear Medicine (LIM43), Department of Radiology and Oncology, Faculdade de Medicina-FMUSP, Universidade de São Paulo, São Paulo 05403-911, SP, Brazil. Electronic address:
Background: Multiple sclerosis (MS) is divided into Relapsing-Remitting (RRMS) and Progressive (PMS) phenotypes, both associated with spinal cord (SC) damage. MS-related disability and SC atrophy are not yet fully understood and can differ across phenotypes. A combined approach using Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) could provide a broader understanding of myelin changes in the cervical SC (CSC) in different MS phenotypes and the associations with disability.
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Institute of Continuum Mechanics and Biomechanics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Dr.-Mack-Straße 81, Fürth, 90762, Germany. Electronic address:
The mechanical properties of brain and spinal cord tissue have proven to be extremely complex and difficult to assess. Due to the heterogeneous and ultra-soft nature of the tissue, the available literature shows a large variance in mechanical parameters derived from experiments. In this study, we performed a series of indentation experiments to systematically investigate the mechanical properties of porcine spinal cord tissue in terms of their sensitivity to indentation tip diameter, loading rate, holding time, ambient temperature along with cyclic and oscillatory dynamic loading.
View Article and Find Full Text PDFCell Rep
December 2024
Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Program in Development, Disease, Models, and Therapeutics, Baylor College of Medicine, Houston, TX 77030, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Center for Cancer Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:
Astrocytes exhibit diverse cellular and molecular properties across the central nervous system (CNS). Recent studies identified region-specific transcription factors (TF) that oversee these diverse properties; how sex differences intersect with region-specific transcriptional programs to regulate astrocyte function is unknown. Here, we show that the TF Nkx6.
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