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An Overview of In Vitro Models of Alcohol-Related Hepatocellular Carcinoma.
Cancer Med
January 2025
GRAP INSERM U1247, Curs, Université Picardie Jules Verne, Amiens, France.
Background: Chronic and excessive alcohol consumption is the leading cause of death due to chronic liver disease. Alcohol-related liver disease (ALD) encompasses a broad spectrum of clinical and pathological features, ranging from asymptomatic and reversible pathologies to hepatocellular carcinoma (HCC), a highly prevalent and deadly liver cancer. Indeed, alcohol consumption is one of the main worldwide etiologies of HCC.
View Article and Find Full Text PDFLong-term health consequences and costs of changes in alcohol consumption in England during the COVID-19 pandemic.
PLoS One
January 2025
HealthLumen Ltd, London, United Kingdom.
Background And Aims: The COVID-19 pandemic led to changes in alcohol consumption in England. Evidence suggests that one-fifth to one-third of adults increased their alcohol consumption, while a similar proportion reported consuming less. Heavier drinkers increased their consumption the most and there was a 20% increase in alcohol-specific deaths in England in 2020 compared with 2019, a trend continuing through 2021 and 2022.
View Article and Find Full Text PDFAssociation of steatotic liver disease with all-cause and cardiovascular mortality among prehypertensive or hypertensive patients.
J Glob Health
January 2025
School of Public Health and Emergency Management, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Background: Prehypertension and hypertension often coexist with non-alcoholic fatty liver disease (NAFLD) during the progression of cardiovascular disease (CVD). International academic liver societies have recently reached a consensus to replace NAFLD with the new term 'steatotic liver disease' (SLD). In this study, we aimed to evaluate the impact of different SLD subtypes on all-cause and CVD mortality in individuals with prehypertension or hypertension.
View Article and Find Full Text PDFAlcohol consumption, drinking patterns and cause-specific mortality in an Australian cohort of 181,607 participants aged 45 years and over.
Public Health
December 2024
The Daffodil Centre, The University of Sydney, a Joint Venture with Cancer Council NSW, Postal Address: PO Box 572, KINGS CROSS, NSW, 1340, Australia.
Objectives: Despite relatively high alcohol consumption in Australia, local evidence regarding drinking and cause-specific mortality is limited. We aimed to quantify the risk of alcohol-related causes of death and to calculate contemporary estimates of absolute risk and population attributable fractions for deaths caused by alcohol consumption in Australia.
Study Design: Prospective cohort study.
New Insights into the Pathogenesis of Alcoholic Liver Disease Based on Global Research.
Dig Dis Sci
January 2025
Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment With Traditional Chinese Medicine Research in Gansu Colleges and University, Gansu University of Chinese Medicine, Lanzhou, China.
Background And Aims: Alcoholic liver disease (ALD) is the leading cause of death among alcohol-related diseases, yet its pathogenesis remains incompletely understood. This article employs data mining methods to conduct an indepth study of articles on ALD published in the past three decades, aiming to elucidate the pathogenesis of ALD.
Methods: Firstly, articles related to the pathogenesis of ALD were retrieved from the Web of Science (WOS) database.
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