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| http://dx.doi.org/10.1001/jamasurg.2024.0424 | DOI Listing |
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Genetic inbreeding load and its individual prediction for milk yield in French dairy sheep.
Genet Sel Evol
January 2025
GenPhySE, Université de Toulouse, INRAE, ENVT, 31326, Castanet-Tolosan, France.
Background: The magnitude of inbreeding depression depends on the recessive burden of the individual, which can be traced back to the hidden (recessive) inbreeding load among ancestors. However, these ancestors carry different alleles at potentially deleterious loci and therefore there is individual variability of this inbreeding load. Estimation of the additive genetic value for inbreeding load is possible using a decomposition of inbreeding in partial inbreeding components due to ancestors.
View Article and Find Full Text PDFRefining fine-mapping: Effect sizes and regional heritability.
PLoS Genet
January 2025
Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Recent statistical approaches have shown that the set of all available genetic variants explains considerably more phenotypic variance of complex traits and diseases than the individual variants that are robustly associated with these phenotypes. However, rapidly increasing sample sizes constantly improve detection and prioritization of individual variants driving the associations between genomic regions and phenotypes. Therefore, it is useful to routinely estimate how much phenotypic variance the detected variants explain for each region by taking into account the correlation structure of variants and the uncertainty in their causal status.
View Article and Find Full Text PDFEnergy-Filtered Quantum States and the Emergence of Nonlocal Correlations.
Phys Rev Lett
December 2024
Université Paris-Saclay, CNRS, LPTMS, 91405, Orsay, France.
Energy-filtered quantum states are promising candidates for efficiently simulating thermal states. We explore a protocol designed to transition a product state into an eigenstate located in the middle of the spectrum; this is achieved by gradually reducing its energy variance, which allows us to comprehensively understand the crossover phenomenon and the subsequent convergence toward thermal behavior. We introduce and discuss three energy-filtering regimes (short, medium, and long), and we interpret them as stages of thermalization.
View Article and Find Full Text PDFMicroplastics accelerate nitrification, shape the microbial community, and alter antibiotic resistance during the nitrifying process.
Sci Total Environ
January 2025
College of Environmental Science and Engineering, Donghua University, Shanghai 201620, China; National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China, Guangdong Key Laboratory of Integrated Agroenvironmental Pollution Control and Management, Institute of Eco-environmental and Soil Sciences, Guangdong Academy of Sciences, Guangzhou 510650, China. Electronic address:
Microplastics (MPs) and antibiotic resistance genes (ARGs) are both emerging pollutants that are frequently detected in wastewater treatment plants. In this study, the effects of various MPs, including polyethylene (PE), polyvinyl chloride (PVC), and biodegradable polylactic acid (PLA), on nitrification performance, dominant microbial communities, and antibiotic resistance during nitrification were investigated. The results revealed that the addition of MPs increased the specific ammonia oxidation rate and specific nitrate production rate by 15.
View Article and Find Full Text PDFFourier analysis of signal dependent noise images.
Sci Rep
December 2024
Cancer Epidemiology Department, H. Lee Moffitt Cancer Center and Research Institute, 12902 Bruce B. Downs Blvd, Tampa, FL, 33612, USA.
An archetype signal dependent noise (SDN) model is a component used in analyzing images or signals acquired from different technologies. This model-component may share properties with stationary normal white noise (WN). Measurements from WN images were used as standards for making comparisons with SDN in both the image domain (ID) and Fourier domain (FD).
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