AI Article Synopsis
- Pembrolizumab is a type of immune checkpoint inhibitor that works by blocking PD-1, showing effectiveness against various solid tumors.
- Unlike traditional chemotherapy, it can lead to immune-related side effects, which are usually mild but can escalate to severe cases needing hospitalization.
- A specific case report highlights a 24-year-old woman who developed challenging pulmonary hypertension as a side effect of pembrolizumab while being treated for alveolar soft part sarcoma.
Article Abstract
Pembrolizumab is an immune checkpoint inhibitor that acts PD-1 blockade. Recent studies have shown its effectiveness in treating various solid organ tumours. However, unlike cytotoxic chemotherapeutic agents, pembrolizumab may cause immune-related adverse effects. These immune-related adverse effects are generally mild, although patients who experience grade-three or higher side effects may require hospitalisation. In particular, cardiopulmonary side effects are associated with high mortality rates. We report the case of a 24-year-old female patient with alveolar soft part sarcoma accompanied by rare and difficult-to-treat pulmonary hypertension induced by pembrolizumab.
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| http://dx.doi.org/10.1080/1120009X.2024.2349858 | DOI Listing |
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