A three-component condensation of 2-unsubstituted imidazole -oxides, 3-ketonitriles, and aldehydes is described. The reaction proceeds sequential Knoevenagel condensation/Michael addition under mild, catalyst-free conditions with various substrates. Furthermore, the corresponding 2-functionalized imidazole -oxides can be further dehydrated to ()-2-aroyl-3-(1-imidazol-2-yl)-acrylonitriles, which may also be directly prepared by changing the reaction conditions as a cascade of Knoevenagel condensation/Michael addition/dehydration.
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