Background: Atezolizumab plus bevacizumab (Atezo/Bev) is frequently selected as the primary systemic therapy for hepatocellular carcinoma (HCC).
Aims: To investigate the outcomes of patients with HCC treated with Atezo/Bev in a real-world setting based on whether they met the inclusion criteria for the phase 3 IMbrave150 trial.
Methods: A total of 936 patients were enrolled. There were 404 patients who met the inclusion criteria of the phase 3 IMbrave150 trial (IMbrave150 group) and 532 who did not (non-IMbrave150 group).
Results: Median progression-free survival (PFS) in the IMbrave150 and non-IMbrave150 groups was 7.4 months and 5.6 months (p = 0.002). Multivariable analysis revealed that non-B, non-C HCC aetiology (hazard ratio [HR], 1.173), α-fetoprotein ≥100 ng/mL (HR, 1.472), Barcelona Clinic Liver Cancer stage ≥ C (HR, 1.318), and modified albumin-bilirubin (mALBI) grade 2b or 3 (HR, 1.476) are independently associated with PFS. Median overall survival (OS) in the IMbrave150 and non-Imbrave150 groups was 26.5 and 18.8 months (p < 0.001). Multivariable analysis revealed that Eastern Cooperative Oncology Group performance status ≥2 (HR, 1.986), α-fetoprotein ≥100 ng/mL (HR, 1.481), and mALBI grade 2b or 3 (HR, 2.037) are independently associated with OS. In subgroup analysis, there were no significant differences in PFS or OS between these groups among patients with mALBI grade 1 or 2a.
Conclusions: Patients who are treated with Atezo/Bev and meet the inclusion criteria for the phase 3 IMbrave150 trial, as well as those who do not meet the inclusion criteria but have good liver function, have a good prognosis for survival.
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http://dx.doi.org/10.1111/apt.18037 | DOI Listing |
J Eat Disord
December 2024
School of Social Sciences, Arts Design and Architecture, University of New South Wales, Sydney, Australia.
Purpose: To examine autonomy within treatment and recovery from longstanding and severe eating disorders (EDs).
Background: The typically early age of onset, high incidence, and prolonged duration of EDs, has a high personal, relational, and financial burden for people who experience them. Current treatment practices rely on the exertion of external control and influence which has profound impacts on people living with EDs as well as the relationship and interactions between them and their treating professionals.
BMC Cardiovasc Disord
December 2024
Department of Cardiology, The Second Affiliated Hospital of Wannan Medical College, 10# Kangfu road, Wuhu, Anhui Province, 241000, China.
Objective: The aim of this study was to investigate the dynamic changes in QTc interval duration among patients with COVID-19 infection before, during, and after infection, in order to assess the short- and potential long-term impact of COVID-19 on cardiac electrophysiology.
Methods: A retrospective analysis was conducted on 303 inpatients diagnosed with COVID-19 who visited a tertiary Grade A hospital in China between August 2022 and December 2023. Inclusion criteria required patients to have at least two electrocardiogram (ECG) recordings at three specific time points: before COVID-19 infection, during acute infection, and after recovery (more than one month post-infection).
BMC Pediatr
December 2024
Independent Researcher, Pune, India.
Background: In recent years, the use of music as a therapeutic and developmental tool for infants, especially within neonatal intensive care units (NICUs), has seen a surge in interest. Despite a growing body of research underscoring the potential benefits of music therapy and music medicine in enhancing infant development and aiding medical practices, the specific characteristics of music that maximize these benefits remain poorly understood.
Objectives: This scoping review aims to provide a comprehensive foundation by mapping the existing literature on passive music listening and identifying gaps, trends, and patterns that are crucial precursors to the development of best practices.
BMC Cancer
December 2024
Department of Cardiothoracic Surgery, Shenzhen Guangming District People's Hospital, Shenzhen, China.
Background: Long non-coding RNA 01116 (linc01116) has been shown to be dysregulated in many tumors, and is closely related to the prognosis. This meta-analysis aimed to examine the correlation between linc01116 expression and cancer prognosis.
Methods: Six electronic databases were searched, and eligible studies were screened based on the inclusion and exclusion criteria.
Res Social Adm Pharm
December 2024
Departamento de Medicina Preventiva y Salud Pública, Universidad de Sevilla, Avenida Doctor Fedriani S/N, CP 41009, Sevilla, Spain.
Background: The rising prevalence of chronic conditions and polypharmacy in the elderly increases the risk of anticholinergic burden, the cumulative effect of multiple anticholinergic drugs. However, no standard exists for assessing anticholinergic burden in these patients, resulting in various anticholinergic scales with differing methodologies and outcomes.
Objectives: To identify existing anticholinergic scales that are applicable to elderly chronic patients and to compare their main characteristics, included drugs and anticholinergic potential scores.
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