Duodenal-type follicular lymphoma (DFL) are uncommon, presenting in both symptomatic and asymptomatic patients, and are generally associated with a benign clinical course. Treatment options include surgery, radiation, and chemotherapy. However, many patients can be managed conservatively with little to no treatment, as 5-year progression-free survival is greater than 70%, and 5-year overall survival ranges from 80% to 94%. Here, we present a case of incidental DFL in a patient with metabolic dysfunction-associated steatohepatitis and cirrhosis. A review of the endoscopic and histologic characteristics, as well as epidemiology, risk factors, and long-term outcomes, may guide management strategies when DFL is encountered.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11075945PMC
http://dx.doi.org/10.14309/crj.0000000000001358DOI Listing

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Article Synopsis
  • - Duodenal-type follicular lymphoma is a rare variant of follicular lymphoma that generally has a good prognosis and can be asymptomatic or present with vague gastrointestinal symptoms.
  • - Diagnosis often happens incidentally during an endoscopic procedure (EGD) when biopsies of duodenal polyps are taken.
  • - A unique case of biopsy-confirmed duodenal-type B cell follicular lymphoma was treated with localized radiotherapy, resulting in complete remission after six months; physicians need to be aware of this rare condition and the possibility of systemic B-cell lymphoma involvement.
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Duodenal-type follicular lymphoma (DFL) is a rare subtype classified by the 5th edition of the WHO and international consensus classifications of lymphoid neoplasms, typically presenting as localized disease with favorable outcomes. This multicenter retrospective study examines 53 Brazilian DFL patients with a median age of 58.2 years (33-85), with males comprising 50% ( = 27).

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Purpose Of Review: This review aims to detail the characteristics and outcomes of duodenal-type follicular lymphoma (DTFL), a rare lymphoma variant. It focuses on integrating recent reports in treatment modalities and highlights emerging insights into the unique biological features of the disease.

Recent Finding: Recent studies confirm the indolent nature of DTFL, with extended follow-up periods showing favorable outcomes under watchful waiting strategies and a notable proportion of patients experiencing spontaneous remission.

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Duodenal-Type Follicular Lymphoma.

Gastro Hep Adv

July 2023

Department of Internal Medicine, King Hamad University Hospital, Busaiteen, Muharraq, Kingdom of Bahrain.

This case report presents the clinical findings, diagnostic evaluation, and treatment options for a 71-year-old female patient with a medical history of hypertension, dyslipidemia, and recurrent urinary tract infections. The patient presented with chronic abdominal pain as the sole symptom. Despite normal laboratory investigations, esophagogastroduodenoscopy and ileocolonoscopy were performed.

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