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Advancing Cancer Diagnosis and Treatment: Integrating Molecular Biomarkers and Emerging Technologies.
Biomed J
January 2025
Department of Biomedical Sciences, Arthur Dugoni School of Dentistry, University of the Pacific, San Francisco, CA, USA. Electronic address:
Cancer biomarkers can be derived from tumor cells or neighboring cells within the tumor microenvironment. Over the past few decades, various molecular markers, including DNA (mutations, copy number variations), RNA (mRNA, microRNA, circular RNA), proteins, and metabolites, have been identified with the aid of rapidly evolving technologies. Some of these markers have demonstrated potential clinical utility, while others have provided new insights into the deregulation of normal molecular and cellular processes that lead to tumorigenesis.
View Article and Find Full Text PDFEndothelial Growth Media Components Alters SARS-CoV-2 Spike-Directed Growth Kinetics.
J Virol Methods
January 2025
Department of Pharmacology, Physiology, and Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA; National Emerging Infectious Diseases Laboratories, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA; Department of Virology, Immunology & Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
Direct SARS-CoV-2 infection of endothelial cells is challenging to study in vitro. To examine whether endothelial cell culture conditions impact the ability of SARS-CoV-2 to infect cells, we evaluated the effects of commercial cell culture media composition on SARS-CoV-2 Spike-directed viral infection. In African Green Monkey kidney epithelial cells (VeroE6), we found that commercial cell culture media (EGM2) produced inhibitory effects on recombinant vesicular stomatitis virus (rVSV-SARS-CoV-2) growth that is not seen in Dulbecco's Modified Eagle Medium (DMEM).
View Article and Find Full Text PDFPreparing the 2025 revision of the International Code of Nomenclature of Prokaryotes.
Int J Syst Evol Microbiol
January 2025
Department of Infectious Disease, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, P.O. Box 7193, SE-402 34 Gteborg, Sweden.
The editorial Board of the (ICNP) - the Prokaryotic Code - has compiled already ratified proposed emendations of the ICNP, together with additional editorial changes and clarifications. These were implemented in a draft 2025 revision of the . To comply with Articles 13(b)(4) and 4(d) of the statutes of the International Committee on Systematics of Prokaryotes (ICSP), a public discussion of the document will start on 1 January (or later if required) 2025, to last for 6 months.
View Article and Find Full Text PDFMultiple Myeloma: Improved Outcomes Resulting from a Rapidly Expanding Number of Therapeutic Options.
Target Oncol
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Berenson Cancer Center, West Hollywood, CA, USA.
Multiple myeloma (MM) is a bone-marrow-based cancer of plasma cells. Over the last 2 decades, marked treatment advances have led to improvements in the overall survival (OS) of patients with this disease. Key developments include the use of chemotherapy, immunomodulatory drugs, proteasome inhibitors, and monoclonal antibodies.
View Article and Find Full Text PDFNavigating the neuroinflammatory network: insights from diverse cell models.
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February 2024
IFIBYNE-UBA-CONICET, Buenos Aires, Argentina.
In this Highlights article, we present insights into the use of simple cell lines in neuroinflammation research, highlighting key findings from our recent investigations. Simple cell lines, including HEK, PC12, SHSY5Y, and N2a cells, provide valuable insights into critical signaling pathways and hidden facets of the neuroinflammatory landscape. Focusing on specific outcomes, including the impact of interleukin-6 (IL-6) and acid-sensing ion channels (ASIC1a), the study sheds light on neuroinflammatory processes.
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