Dietary alleviated Typhimurium infection and suppressed Jak/Stat pathway in rabbits.

This study aimed to investigate the effect of a  DPP8 supplementation on the growth performance, pathogenic invasion, inflammation and pathogen resistance signal pathway in rabbits infected with Typhimurium ( Typhimurium). The treatments included a negative control, a positive control with an  Typhimurium infection and a positive control plus DPP8 at 10, 10 or 10 cfu/kg of diet using 300 weaned rabbits. The results showed that supplementing with DPP8 improved ( < 0.05) the feed intake, body weight gain and feed efficiency compared to the positive control. Also, DPP8 decreased ( < 0.05) the  Typhimurium colonisation and translocation, serum IL-1β, IL-6 and TNF-α, and intestinal mucosa mRNA expressions of the inflammatory mediators Janus kinase (Jak) 2, the signal transducer and activator of transcription (Stat) 1 and 3 at 7 and 14 d post administration. The dose analysis of DPP8 showed linear increases ( ≤ 0.007) in the feed intake and body weight gain, but linear decreases ( ≤ 0.022) in the  Typhimurium loads, IL-1β, IL-6 and Jak2. It is concluded that DPP8 can be used as a supportive probiotic against an  Typhimurium infection and it possibly plays a direct or indirect role in the downregulation of the Jak/Stat pathway in rabbits.