AI Article Synopsis
- Gelatin hydrogel nonwoven fabrics, known as Genocel, are being studied for their potential to improve wound healing in diabetic mice, specifically for difficult-to-treat wounds like diabetic foot ulcers, by enhancing blood vessel formation.
- In the study, both Genocel and a standard skin substitute (Pelnac) were tested on skin defects, and their healing effects were assessed through various histological analyses.
- Results showed that Genocel had comparable wound healing effects to Pelnac, with the main difference being a lower number of M2 macrophages in the Genocel-treated wounds on day 7, suggesting both materials could be effective in managing diabetic ulcers.
Article Abstract
Background: Gelatin hydrogel nonwoven fabrics (Genocel) are three-dimensional gelatin scaffolds that provide cells with space for proliferation, migration, and differentiation. They are expected to be an effective wound healing modality to treat intractable wounds, such as diabetic foot ulcers, because they enhance early neovascularization when used as a skin substitute. In this study, we explored the healing process of Genocel applied to skin defects in diabetic mice and compared it with that of a conventional skin substitute, Pelnac.
Methods: Genocel and Pelnac sheets were used to treat skin defects on the backs of diabetic mice. On days 7 and 14, the remaining wound area was evaluated and specimens were harvested for HE, Azan, anti-CD31, CD68, and CD163 staining to assess neoepithelialization, granulation tissue formation, capillary formation, and macrophage infiltration.
Results: Wounds treated with Genocel showed a wound healing process comparable to that of wounds treated with Pelnac. No significant differences were observed in the remaining wound area, neoepithelial length, granulation formation, number of pan-macrophages, or M2 ratio on days 7 and 14. The only significant difference was the number of induced M2 macrophages, which was higher in Pelnac group than in the Genocel group on day 7 (p < 0.05).
Conclusions: Genocel showed similar healing effects in diabetic wounds as Pelnac and is considered an effective wound management modality for diabetic ulcers.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11074961 | PMC |
| http://dx.doi.org/10.1016/j.reth.2024.04.003 | DOI Listing |
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