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Cryptococcus neoformans/gattii and Histoplasma capsulatum var. capsulatum infections on tissue sections: diagnostic pitfalls and relevance of an integrated histomolecular diagnosis.
Med Mycol
December 2024
UR 3738 - CICLY - Equipe Inflammation et immunité de l'épithélium respiratoire, Faculté de Médecine Lyon-Sud Charles Mérieux, Université Claude Bernard Lyon 1, Lyon, France.
Cryptococcus neoformans/gattii and Histoplasma capsulatum var. capsulatum may present atypical histopathological features inducing diagnostic errors. We aimed to estimate the frequency of these atypical features on formalin-fixed tissue samples (FT) and to assess the relevance of an integrated histomolecular diagnosis using specific Histoplasma capsulatum PCR and panfungal PCR followed by Sanger sequencing and/or targeted-massive parallel sequencing (MPS).
View Article and Find Full Text PDFMulti-site esterification: a tunable, reversible strategy to tailor therapeutic peptides for delivery.
Mol Syst Des Eng
November 2024
Department of Chemical Engineering, University of Virginia Charlottesville VA 22903 USA +1 434 243 3628.
Peptides are naturally potent and selective therapeutics with massive potential; however, low cell membrane permeability limits their clinical implementation, particularly for hydrophilic, anionic peptides with intracellular targets. To overcome this limitation, esterification of anionic carboxylic acids on therapeutic peptides can simultaneously increase hydrophobicity and net charge to facilitate cell internalization, whereafter installed esters can be cleaved hydrolytically to restore activity. To date, however, most esterified therapeutics contain either a single esterification site or multiple esters randomly incorporated on multiple sites.
View Article and Find Full Text PDFComBatLS: A location- and scale-preserving method for multi-site image harmonization.
bioRxiv
July 2024
Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
Recent work has leveraged massive datasets and advanced harmonization methods to construct normative models of neuroanatomical features and benchmark individuals' morphology. However, current harmonization tools do not preserve the effects of biological covariates including sex and age on features' variances; this failure may induce error in normative scores, particularly when such factors are distributed unequally across sites. Here, we introduce a new extension of the popular ComBat harmonization method, ComBatLS, that preserves biological variance in features' locations and scales.
View Article and Find Full Text PDFMassive multi-site audit projects: preparation, organization, and project management.
JBI Evid Implement
May 2024
Nanfang Hospital, Southern Medical University, Guangzhou, PR China.
Understanding knowledge, attitudes and practices on Ebola Virus Disease: a multi-site mixed methods survey on preparedness in Rwanda.
BMC Public Health
December 2023
Laboratory of Emerging Infectious Diseases, Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Canada.
Background: The overall goal of this survey was to understand the knowledge, attitudes, and practices related to the Ebola Virus Disease (EVD) in Rwanda.
Methods: This mixed-method cross-sectional survey was conducted in five selected districts of Rwanda. Quantitative data were collected from 1,010 participants using Kobo Collect Software and the analysis was performed using SPSS and Python software.
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