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Papilledema Due to Immune Checkpoint Inhibitor-Associated Subdural Effusions.
J Neuroophthalmol
May 2024
Departments of Ophthalmology (EB, HJR) and Radiology (CJS), University of Virginia, Charlottesville, Virginia.
Fanconi anemia neuroinflammatory syndrome: brain lesions and neurologic injury in Fanconi anemia.
Blood Adv
June 2024
Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Fanconi anemia (FA) is a complex inherited bone marrow failure syndrome characterized by chromosomal instability and defective DNA repair, causing sensitivity to DNA interstrand crosslinking agents. Our understanding of the full adult phenotype of the disease continues to evolve, because most patients with FA died of marrow failure in the first decade of life before more recent advances in allogeneic hematopoietic cell transplantation. Herein, we report a previously undescribed, clinically concerning, progressive neurologic syndrome in patients with FA.
View Article and Find Full Text PDFPapillitis associated with IgLON5 autoimmunity: A novel clinical phenotype.
J Neuroimmunol
March 2024
Department of Neurology, Mayo Clinic, Rochester, USA; Center of MS and Autoimmune Neurology, Mayo Clinic, Rochester, USA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, USA. Electronic address:
Objectives: To describe papillitis as a clinical phenotype of IgLON5 autoimmunity.
Methods: We retrospectively reviewed patients with IgLON5 autoimmunity who had optic neuropathy, optic neuritis, or optic disc edema. Sera from patients with recurrent papillitis were tested for IgLON5 antibodies.
Neuro-Ophthalmic Adverse Events of COVID-19 Infection and Vaccines: A Nationwide Cohort Study.
Invest Ophthalmol Vis Sci
November 2023
Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
Purpose: To evaluate the association of COVID-19 infection and vaccination with neuro-ophthalmic adverse events.
Methods: In this nationwide population-based retrospective cohort study, 8,498,353 patients were classified into three groups: control, COVID-19 infection, and COVID-19 vaccination. We conducted separate analyses for the early phase (within 60 days) and late phases (61-180 days) to estimate the incidence rates and hazard ratio (HR) for each neuro-ophthalmic adverse event.
Idiopathic Intracranial Hypertension Secondary to Chronic Inflammatory Demyelinating Polyradiculoneuropathy.
Cureus
August 2023
Neurology, State University of New York Upstate Medical University, Syracuse, USA.
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is the most common immune-mediated inflammatory polyneuropathy, defined as progressive or relapsing symptoms for over two months with pathological or electrophysiological evidence of peripheral nerve demyelination. Papilledema is optic nerve head edema secondary to increased intracranial pressure or infiltrative/infectious etiologies. Regardless of the cause, visual loss is one of the feared manifestations due to optic nerve damage.
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